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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Epidemiology and outcome of idiopathic generalized epilepsy in adults
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Epidemiology and outcome of idiopathic generalized epilepsy in adults

机译：成人特发性广义癫痫的流行病学与结果

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Background and purpose Drug‐resistant idiopathic generalized epilepsy (IGE) remains challenging despite a favourable overall prognosis of IGE, and little is known about basic epidemiology and long‐term outcome of drug‐resistant IGE. The aim of the study was to describe the incidence, prevalence and outcome of IGE in an unbiased, population‐based cohort. Methods In 2014–2018, all patients (≥17?years) with IGE inhabiting the island of Funen (496?000 inhabitants) were recruited. The socioeconomic and clinical information available for 406 individuals was assessed. Median follow‐up was 15?years. Results The average IGE incidence (2008–2017) was 2.9/100?000 inhabitants/year. The point prevalence of identifiable IGE patients was 1.0/1000 adults (juvenile myoclonic epilepsy 0.4/1000; absence epilepsy 0.3/1000, epilepsy with generalized tonic–clonic seizures alone 0.3/1000); 92.1% of the patients were diagnosed before 25?years of age. When correcting for unequal age distribution in the cohort, 1102 people on the island of Funen fulfilled the diagnostic criteria for IGE at the age of 25 (estimated prevalence 2.7/1000 adults). In the year before data closure, 121 patients reported seizures. Fifty patients met the definition of drug‐resistant IGE (12.1% of the cohort, 4.5% of the estimated 1102 IGE patients). The average seizure burden of all patients with drug‐resistant IGE was 2.2 generalized tonic–clonic seizures per year; only 14 patients suffered more than two generalized tonic–clonic seizures per year. Drug‐resistant IGE was associated with an increased risk of requiring treatment for affective disorders and a reduced probability of working full time. Conclusion Idiopathic generalized epilepsy was associated with a low risk of persistent drug‐resistant seizures requiring specialist medical attention. Drug resistance was associated with a negative socioeconomic outcome.
机译：背景和目的抗药性特发性广义癫痫（IgE）仍然挑战，尽管IgE是有利的总体预后，但对耐药IgE的基本流行病学和长期结果很少。该研究的目的是描述在无偏见的人口群体中IgE的发病率，患病率和结果。方法在2014 - 2018年，招募了所有患者（≥17岁）与IgE居住的IgE（496 000居民）被招募。可评估406人可用的社会经济和临床信息。中位后续时间为15？多年。结果平均IgE入射（2008-2017）为2.9 / 100？000居民/年。可识别的IgE患者的患病率为1.0 / 1000成人（青少年肌阵挛性癫痫0.4 / 1000;缺乏癫痫0.3 / 1000，癫痫与广义滋补克隆癫痫发作0.3 / 1000）; 92.1％的患者在25岁之前被诊断出来。纠正在队列中不平等的年龄分布时，施加岛上的1102人达到了25岁的IgE诊断标准（估计患病率2.7 / 1000成年人）。在数据结束前一年，121名患者报告癫痫发作。五十名患者达到耐药IgE的定义（群组的12.1％，4.5％的估计1102伊埃患者）。所有耐药IgE患者的平均癫痫发作负担是每年2.2概述滋补克隆癫痫发作;只有14名患者每年遭受两种以上的普遍化助剂障碍癫痫发作。耐药IgE与需要治疗情感障碍的风险增加以及全职工作的概率降低有关。结论特发性广义癫痫与需要专科医生的持续耐药癫痫发作的低风险有关。耐药性与负面的社会经济结果有关。

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