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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Uric acid level and risk of symptomatic intracranial haemorrhage in ischaemic stroke treated with endovascular treatment
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Uric acid level and risk of symptomatic intracranial haemorrhage in ischaemic stroke treated with endovascular treatment

机译：血管内治疗缺血性脑卒中中尿酸水平与症状颅内出血风险

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Background and purpose There are limited data on the association between uric acid (UA) and symptomatic intracranial haemorrhage (SICH) in patients who have undergone mechanical thrombectomy [endovascular treatment (EVT)]. In the present study, we aimed to investigate the role of serum UA level in SICH after EVT in a real‐world practice. Methods Patients were selected from the Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke (ACTUAL) registry. SICH was identified using the Heidelberg Bleeding Classification. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and SICH. Results Among 611 enrolled patients, 90 (14.7%) were diagnosed with SICH within 72?h after EVT. Patients with SICH had a significantly higher level of serum UA (median, 341.0 vs. 302.0?μmol/L; P ?=?0.003) than those without SICH. Univariate logistic regression analysis indicated that patients with UA levels in the fourth quartile, compared with the first quartile, were more likely to have SICH (odds ratio, 2.846; 95% confidence intervals, 1.429–6.003; P ?=?0.003). The association remained significant after multivariable adjustment for potential confounders. Furthermore, the multiple‐adjusted spline regression model showed an inverted U‐shaped association between UA and SICH ( P ?=?0.047 for non‐linearity). Conclusion Our study indicated that increased serum UA level was independently associated with SICH after EVT in acute ischaemic stroke.
机译：背景和目的在经历机械血栓切除术后[血管内治疗（EVT）]的患者中存在有限的数据关于尿酸（UA）和症状颅内出血（SICH）之间的关系。在本研究中，我们旨在探讨eSHT在真实世界实践中的血清中血清UA水平的作用。方法选中患者急性前循环缺血性卒中（实际）注册表的血管内治疗。使用海德堡出血分类来确定Sich。进行多变量逻辑回归分析以探讨血清UA和SICH之间的关系。结果611名患者中，90例（14.7％）被诊断患有72升后的SICH。患有SICH的患者血清UA水平明显高（中位数，341.0与302.0μmol/ L; p？= 0.003），而不是没有SICH的血清UA。单变量逻辑回归分析表明，与第四个四分位数相比，第四四分位数的UA水平的患者更可能具有SICH（赔率比，2.846; 95％置信区间，1.429-6.003; p？= 0.003）。在多变量调整的潜在混淆后，该协会仍然显着。此外，多调整的花键回归模型显示UA和SICH之间的倒U形关联（P？=Δ0.047，用于非线性）。结论我们的研究表明，在急性缺血性卒中evt后，血清血清uA水平的增加与Sich独立相关。

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