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The experience of chemotherapy-induced peripheral neuropathy in adult cancer patients: a qualitative thematic synthesis

机译：化疗诱导的成人癌症患者外周神经病变的经验：定性专题合成

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The aim of this review was to systematically identify, appraise and synthesise qualitative research evidence on the experience of adult cancer patients living with chemotherapy-induced peripheral neuropathy (CIPN). A systematic search of the literature was performed in September 2015. Qualitative studies were included if they investigated CIPN and patient experience. Quality of the articles was appraised using an adapted version of the Critical Appraisal Skill Programme Checklist for Qualitative Research (CASP 2014). Themes were identified using the thematic synthesis approach proposed by Thomas and Harden [BMC Medical Research Methodology 8 (2008) 45]. Five articles presented findings generated by 88 patients who had all received neurotoxic chemotherapy. Sample sizes from included studies varied from 1 to 28 patients; all studies originated from America and were published between 2005 and 2015. Four analytical themes emerged: (1) CIPN is an unclear experience, (2) a less important risk, (3) impact on quality of life and (4) a feature of cancer survivorship. In conducting this synthesis, the lack of qualitative evidence in this specific condition is evident. Further studies are needed outside of America, to focus on CIPN risk communication approaches by healthcare professionals, patient understanding and perception of CIPN risk and interventions to promote early detection of CIPN including effective reporting and assessment.
机译：本综述的目的是系统地识别，评估和综合有关患有化疗诱导的周围神经病变（CIPN）的成人癌症患者的经验的定性研究证据。在2015年9月进行了对文献的系统搜索。如果调查CIPN和患者体验，则包括定性研究。使用质量研究的关键评估技能核查表（2014年CASP）进行评估文章的质量。使用Thomas和Harden提出的专题合成方法来确定主题[BMC医学研究方法8（2008）45]。五篇文章呈现出88名患者产生的结果，患有所有接受神经毒性化疗的患者。包括的研究尺寸从1到28名患者中变化不等;所有研究起源于美国，并在2005年至2015年出版。出现了四个分析主题：（1）CIPN是一个不清楚的经验，（2）不太重要的风险，（3）对生活质量的影响和（4）的影响癌症生存。在进行这种合成时，明显缺乏这种特定条件的定性证据。在美国以外需要进一步的研究，专注于通过医疗保健专业人员，患者理解和对CIPN风险的感知和干预措施的CIPN风险通信方法，以促进CIPN的早期检测，包括有效的报告和评估。

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