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首页> 外文期刊>Advances in Experimental Medicine and Biology >NOTCH-SIGNALING AND NONMELANOMA SKIN CANCER: An Ancient Friend, Revisited
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NOTCH-SIGNALING AND NONMELANOMA SKIN CANCER: An Ancient Friend, Revisited

机译：刻痕信号和非黑色素皮肤癌：一个古老的朋友，再访

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摘要

In humans and other species, Notch-signaling is of critical importance for carcinogenesis in several organs, including the skin. Interestingly, Notch-signaling appears to exert opposite roles in skin carcinogenesis as compared to carcinogenesis in other tissues. While the Notchl receptor (Notchl) acts as a proto-oncogene in most tissues, it has been shown that Notchl deletion in epidermal keratinocytes causes skin carcinogenesis. Recent results indicate that loss of Notchl is not involved in the initiating event of multistage skin carcinogenesis, but acts as a skin cancer-promoting event. Moreover, recent findings underline the importance of multiple other factors, including the microenvironment, for Notch signaling in skin carcinogenesis. It can be speculated that pharmacologic modulation of Notch signaling may be an interesting target for the prevention and therapy of skin cancer.
机译：在人类和其他物种中，Notch信号对于包括皮肤在内的多个器官的致癌作用至关重要。有趣的是，与其他组织的癌变相比，Notch信号似乎在皮肤癌变中发挥相反的作用。尽管Notch1受体（Notch1）在大多数组织中充当原癌基因，但已证明表皮角质形成细胞中Notch1缺失会引起皮肤癌变。最近的结果表明，Notch1的丧失不参与多阶段皮肤致癌的起始事件，而是作为促进皮肤癌的事件。而且，最近的发现强调了皮肤癌发生过程中Notch信号传导的许多其他因素，包括微环境，的重要性。可以推测，Notch信号传导的药理调节可能是预防和治疗皮肤癌的有趣目标。

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