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首页> 外文期刊>European journal of clinical pharmacology >Effectiveness of using STOPP/START criteria to identify potentially inappropriate medication in people aged >= 65 years with chronic kidney disease: a randomized clinical trial
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Effectiveness of using STOPP/START criteria to identify potentially inappropriate medication in people aged >= 65 years with chronic kidney disease: a randomized clinical trial

机译：使用停止/开始标准的有效性，以鉴定慢性肾脏疾病（慢性肾脏病）= 65年的潜在不恰当的药物：随机临床试验

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Purpose Polypharmacy and inappropriate prescribing are common in elderly with chronic kidney disease (CKD). This study identified potentially inappropriate prescriptions (PIPs) and potential prescribing omissions (PPOs) using the Screening Tool of Older Persons' Prescriptions (STOPP) and the Screening Tool to Alert doctors to the Right Treatment (START) criteria in elderly with advanced CKD and determined the effect of a medication review on medication adherence and health-related quality of life (HRQoL). Methods The intervention consisted of a medication review using STOPP/START criteria with a recommendation to a nephrologist or similar review without a recommendation. End points were prevalence of PIP and PPO, medication adherence, and HRQoL. Group differences in outcomes were assessed using a generalized linear mixed model. The trial was registered under (ID: NCT02424786). Results We randomized 180 patients with advanced CKD (mean age 77 years, 23% female). The prevalence of PIPs and PPOs in the intervention group was 54% and 50%, respectively. The odds of PPOs were lower in the intervention than the control group (OR 0.42, 95% CI 0.19-0.92, p = 0.032), while there was no intergroup difference in the number of PIPs (OR 0.57, CI 0.27-1.20, p = 0.14). There was no difference in changes in medication adherence or HRQoL from baseline to 6 months between the groups. Conclusions The intervention with the STOPP/START criteria identified a high prevalence of inappropriate medications in the elderly with advanced CKD and reduced the number of PPOs. However, there was no detectable impact of the intervention on medication adherence or HRQoL.
机译：目的在慢性肾病（CKD）的老年人中常见于多酚和不适当的处方。本研究确定了使用较老年人的处方（停止）的筛选工具和筛选工具的屏幕工具和筛选工具，识别出潜在不适当的处方（PIPS）和潜在的规定遗漏（PPO），以提醒医生以先进的CKD为老年人的正确治疗（开始）标准并确定药物综述对药物依从性和健康相关生活质量（HRQOL）的影响。方法使用STOPP / Start标准的干预由药物检查或类似审查的推荐组成的药物审查组成。终点是PIP和PPO，药物粘附和HRQOL的患病率。使用广义的线性混合模型评估结果的组差异。该试验在（ID：NCT02424786）下注册。结果我们随机化了180名高级CKD患者（平均年龄77岁，女性23％）。干预组中PIP和PPO的患病率分别为54％和50％。介入的PPOS的几率低于对照组（或0.42,95％CI 0.19-0.92，P = 0.032），而PIPS数量（或0.57，CI 0.27-1.20，P没有相互作用差异= 0.14）。从基线到组之间的3个月内的药物申诉或HRQOL的变化没有差异。结论与停止/起始标准的干预确定了老年人在高级CKD中的不适当药物的患病率高，并减少了PPO的数量。然而，干预对药物粘附或HRQOL没有可检测的影响。

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