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首页> 外文期刊>European journal of pediatric surgery = Zeitschrift fur Kinderchirurgie >Ephrin-B1,-B2, and-B4 Expression is Decreased in Developing Diaphragms and Lungs of Fetal Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia
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Ephrin-B1,-B2, and-B4 Expression is Decreased in Developing Diaphragms and Lungs of Fetal Rats with Nitrofen-Induced Congenital Diaphragmatic Hernia

机译：在胎儿诱导的先天性膈疝中，胎儿大鼠的膈肌和肺部减少ephrin-B1，-B2和-B4表达

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Introduction Congenital diaphragmatic hernia (CDH) is assumed to originate from a malformation of the amuscular mesenchymal component of the primordial diaphragm. Mutations in ephrin-B1, a membrane protein that is expressed by mesenchymal cells, have been found in newborn infants with CDH and associated pulmonary hypoplasia (PH), highlighting its important role during diaphragmatic and airway development. Ephrin-B1, -B2, and -B4 are expressed in fetal rat lungs and have been identified as key players during lung branching morphogenesis. We hypothesized that diaphragmatic and pulmonary expression of ephrin-B1, -B2, and -B4 is decreased in the nitrofen-induced CDH model.
机译：介绍先天性膈疝（CDH）源自原始隔膜的汞间充质成分的畸形。 Ephrin-B1中的突变，一种由间充质细胞表达的膜蛋白，已在新生儿婴儿中发现，CDH和相关肺发育不全（pH），突出了在膈肌和气道发育过程中的重要作用。 Ephrin-B1，-B2和-B4在胎儿大鼠肺中表达，并在肺部分支形态发生期间被鉴定为关键球员。 我们假设硝基诱导的CDH模型中的Ephrin-B1，-B2和-B4的膈肌和肺动力表达降低。

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