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首页> 外文期刊>European journal of gynaecological oncology >Prognostic factors for lymph node metastasis in high-grade endometrial cancer
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Prognostic factors for lymph node metastasis in high-grade endometrial cancer

机译：高级子宫内膜癌淋巴结转移的预后因素

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Objective: To study what are the prognostic factors of lymph nodes (LN) metastasis in all types of high-grade endometrial carcinoma (EC): poorly differentiated endometrioid carcinoma (ECG3), clear-cell carcinoma (CCC), uterine serous carcinoma (USC), and carcinosarcoma (CS). Materials and Methods: A multicentric, retrospective cohort study including 252 patients with lymphadenectomy (LND) (pelvic and /or para-aortic). The authors assessed the predictive value for LN metastasis of myometrial invasion, lymphovascular space involvement (LVSI), isthmus affectation, tumor size, presurgical CA 12.5 value, Ki67 expression, and p53 immunohistochemistry in samples from hysterectomy. Results: Of the 252 patients with high-grade EC that were included in the study, 94 had ECG3, 69 USC, 43 CCC, and 46 CS. Pelvic LND was performed in 248 (98.4%) patients and para-aortic in 111 (44%). No significant differences were observed in the number of LN resected according to their histological subtype (p = 0.161; para-aortic, p= 0.051). The authors found positive LN in 79 (31.3%) of the 252 patients. Deep myometrial invasion (OR 6.006 IC 95%: 2.715-13.287, p <= 0.001), LVSI (OR 11.805 IC 95%: 5.829-23.907, p <= 0.001), isthmus affectation (OR 5.481 IC: 95% 2.743-10.952, p <= 0.001). and abnormal presurgical CA 12.5 value (p = 0.006) were significantly associated with the presence of metastasis confirmed by histological examination. The remaining factors included in the study were not observed to have any predictive value for I,N metastasis. Conclusions: Myometrial invasion, LVSI, uterine istlunus affectation, and preoperative value of CA 12.5 were found to be predictor factors of LN metastasis in high-grade EC. Tumor size, Ki67 expression, and p53 were not observed to have any predictive value for LN metastasis.
机译：目的：研究所有类型的高级子宫内膜癌（EC）中淋巴结（LN）转移的预后因素是什么：子宫内疗中癌（ECG3），透明细胞癌（CCC），子宫浆液癌（USC） ）和癌肉瘤（CS）。材料与方法：多中心，回顾性队列研究，包括252例淋巴结切除术（LND）（盆腔和/或盆腔主动脉）。作者评估了来自子宫切除术的样品中的Myomometrial侵袭，淋巴血管空间侵袭，淋巴血管空间受累（LVSI），淋巴血管空间，肿瘤大小，ki67表达和P53免疫组化的预测值。结果：在研究中包含的252例高级EC患者中，94例ECG3,69 USC，43 CCC和46CS。骨盆LND于111名（44％）中的248例（98.4％）患者和帕拉主动脉。根据其组织学亚型切除的LN数未观察到显着差异（p = 0.161; para-主动脉，p = 0.051）。作者发现了252名患者的79名（31.3％）的阳性LN。深度闭塞侵袭（或6.006 IC 95％：2.715-13.287，P <= 0.001），LVSI（或11.805 IC 95％：5.829-23.907，P <= 0.001），斯蒂姆造成（或5.481克：95％2.743-10.952 ，p <= 0.001）。和异常的预设Ca 12.5值（p = 0.006）与组织学检查证实的转移存在显着相关。未观察到该研究中包含的其余因素对I，N转移具有任何预测值。结论：肌瘤侵袭，LVSI，子宫肌动效应和术前值Ca 12.5是高档EC中LN转移的预测因素。未观察到肿瘤大小，Ki67表达和P53对LN转移具有任何预测值。

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