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首页> 外文期刊>European journal of gynaecological oncology >Prolonged overall survival in Stage IV patient with malignant transformation from ovarian mature cystic teratoma by combination therapy including radiotherapy: a case report and the review of literature
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Prolonged overall survival in Stage IV patient with malignant transformation from ovarian mature cystic teratoma by combination therapy including radiotherapy: a case report and the review of literature

机译：延长阶段IV患者的整体存活，通过组合治疗，包括放射治疗的卵巢成熟囊性畸胎瘤的恶性转化：案例报告和文学审查

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摘要

Background: The prognosis of Stage IV disease of malignant transformation from mature cystic teratoma (MT-MCT) of the ovary in is extremely poor, and there has been no standard therapy established for MT-MCT. A case with Stage IV tumor that achieved disease-free survival of 19 months treated with radiotherapy, in addition to surgery and chemotherapy is reported, with a review of the literature. Clinical case: A 57-year-old Japanese woman, gravida 3, para 2, received total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymph nodes biopsy, and Hartmann's operation. Although tumors in the pelvis were completely resected, residual tumor was present in liver. The pathological findings revealed squamous cell carcinoma (SCC) arising from MCT, and her diseases were diagnosed as Stage IV MT-MCT. Postoperatively she received one cycle of combination chemotherapy of paclitaxel and carboplatin (TC). Then stereotactic radiation therapy (SRT, 48 Gy/four fractions) for liver metastasis and additional five cycles of TC was conducted, and the liver metastasis achieved complete response. After 19 months of disease-free interval, relapsed tumors in para-aortic nodes were observed, and radiation therapy (50 Gy/27 fractions) was administered. Although the lesions achieved partial response, recurrence was observed after eight months, and the patient died of disease after achieving overall survival of 30 months. Conclusion: Radiotherapy could be an effective procedure for advanced SCC from MCT, even when the tumors are metastatic or recurrent.
机译：背景：卵巢成熟囊性畸胎瘤（MT-MCT）的恶性转化阶段阶段疾病的预后极为差，并且没有为MT-MCT建立的标准治疗。据报道，除了外科和化疗外，还达到了术后IV肿瘤的患者，可达到无疗法治疗19个月的疾病存活。临床案例：一名57岁的日本女性，Gravida 3，2，2，收到的子宫切除术，双侧Salpingo-Oophorectomy，盆腔淋巴结活检，以及Hartmann的操作。尽管骨盆中的肿瘤被完全切除，但肝脏中存在残留的肿瘤。病理发现揭示了MCT产生的鳞状细胞癌（SCC），并且疾病被诊断为阶段IV MT-MCT。术后她接受了紫杉醇和卡铂（TC）的一个组合化疗的循环。然后进行肝转移的立体定向辐射治疗（SRT，48 GY /四分之一）和额外的TC循环，肝转移达到完全反应。经过19个月的无病间隔后，观察到帕拉主动脉节点的复发肿瘤，并施用放射治疗（50 Gy / 27分数）。虽然病变达到了部分反应，但在八个月后观察到复发，患者在实现30个月的整体存活后死亡。结论：放射疗法可能是来自MCT的高级SCC的有效方法，即使肿瘤是转移性或复发的。

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    H. Matsuura; M. Takano; M. Miyamoto; T. Shibutani; T. Yoshikawa; K. Furuya;

  • 作者单位

    Department of Obstetrics and Gynecology National Defense Medical College Tokorozawa (Japan);

    Department of Clinical Oncology National Defense Medical College Tokorozawa (Japan);

    Department of Obstetrics and Gynecology National Defense Medical College Tokorozawa (Japan);

    Department of Obstetrics and Gynecology National Defense Medical College Tokorozawa (Japan);

    Department of Clinical Oncology National Defense Medical College Tokorozawa (Japan);

    Department of Obstetrics and Gynecology National Defense Medical College Tokorozawa (Japan);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇产科学;
  • 关键词

    Ovary; Malignant transformation; Mature cystic teratoma;

    机译：卵巢;恶性转化;成熟囊性畸胎瘤;

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