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首页> 外文期刊>European Journal of Haematology >The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients
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The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients

机译：Tranexamic acid的许多作用：医学和手术患者中TXA的临床适应症概述

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Abstract Clinically significant bleeding can occur as a consequence of surgery, trauma, obstetric complications, anticoagulation, and a wide variety of disorders of hemostasis. As the causes of bleeding are diverse and not always immediately apparent, the availability of a safe, effective, and non‐specific hemostatic agent is vital in a wide range of clinical settings, with antifibrinolytic agents often utilized for this purpose. Tranexamic acid (TXA) is one of the most commonly used and widely researched antifibrinolytic agents; its role in postpartum hemorrhage, menorrhagia, trauma‐associated hemorrhage, and surgical bleeding has been well defined. However, the utility of TXA goes beyond these common indications, with accumulating data suggesting its ability to reduce bleeding and improve clinical outcomes in the face of many different hemostatic challenges, without a clear increase in thrombotic risk. Herein, we review the literature and provide practical suggestions for clinical use of TXA across a broad spectrum of bleeding disorders.
机译：摘要临床显着的出血可以作为手术，创伤，产科并发症，抗凝和止血障碍的各种障碍发生。随着出血的原因是多样的，并且并不总是立即明显，安全，有效和非特异性的止血剂在各种临床环境中至关重要，并且通常用于此目的的防纤维蛋白溶剂剂。 Tranexamic酸（TXA）是最常用和最广泛研究的抗纤维蛋白溶解剂之一;它在产后出血中的作用，美甲群，创伤相关的出血和手术出血已经很好地定义。然而，TXA的效用超出了这些常见的迹象，积累了数据，表明其能够减少出血的能力，并在面对许多不同的止血挑战面前改善临床结果，而不会明显增加血栓形成风险。在此，我们审查了文献，并提供了临床使用TXA跨越出血障碍的实际建议。

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