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首页> 外文期刊>European Journal of Radiology >Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study
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Diffusion-weighted imaging in assessing renal pathology of chronic kidney disease: A preliminary clinical study

机译：评估慢性肾病肾病理学的扩散加权成像：初步临床研究

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摘要

Objective To investigate the clinical potential of diffusion-weighted imaging (DWI) in assessing renal pathology of chronic kidney disease (CKD). Methods Seventy-one CKD patients and twelve healthy volunteers were examined using DWI with prospective acquisition correction. Renal biopsy specimens from the CKD patients were scored based on the severity of renal pathology and to confirm pathology type. CKD patients were divided into three groups according to pathology scores: mild, moderate, or severe. The association between renal apparent diffusion coefficient (ADC) values and pathology scores was investigated using Pearson's correlation and single factor analysis of variance. Multiple linear regression analysis was performed to explore associations between renal ADC values and pathology score, glomerular filtration rate, serum creatinine, and age. The Kruskal-Wallis H test was conducted to compare ADC values and pathology type. Results Renal ADC values correlated negatively with pathology scores (r = -0.633, P 0.001). The ADC values among the four groups (mild, moderate, severe impairment, and controls) were significantly different (F = 19.512, P 0.001). However, when patients were stratified by pathology type, no significant differences were found in ADC values among these groups (χ2 = 9.929, P = 0.270). Further multiple linear regression analysis showed that only the pathology score and ADC values were related (t = -4.586, P = 0.000). Conclusions DWI has clinical potential in assessing the severity of renal pathology in CKD and shows promise as a non-invasive and effective technique to guide therapy and follow-up.
机译：目的探讨扩散加权成像（DWI）评估慢性肾病（CKD）的肾脏病理学的临床潜力。方法使用DWI进行七十一台CKD患者和12名健康志愿者，具有前瞻性收购纠正。 CKD患者的肾活检标本是基于肾病病理的严重程度和确认病理型的分别评分。 CKD患者根据病理分数分为三组：轻度，中度或严重。使用Pearson的相关性和异常单因素分析研究了肾上表观扩散系数（ADC）值和病理学分数之间的关联。进行多元线性回归分析以探索肾ADC值与病理评分，肾小球过滤速率，血清肌酐和年龄之间的关联。进行Kruskal-Wallis H测试以比较ADC值和病理型。结果肾ADC值与病理学分数负相关（R = -0.633，P <0.001）。四组（轻度，中度，严重损伤和对照）中的ADC值显着不同（f = 19.512，p <0.001）。然而，当患者通过病理型分层时，在这些基团之间没有发现adc值中的显着差异（χ2= 9.929，p = 0.270）。进一步的多元线性回归分析表明，只有病理得分和ADC值相关（t = -4.586，p = 0.000）。结论DWI具有评估CKD中肾病理学严重程度的临床潜力，并将承诺作为指导治疗和随访的非侵入性和有效技术。

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  • 来源
    《European Journal of Radiology》 |2014年第5期|共7页
  • 作者

    LiQ.; LiJ.; ZhangL.; ChenY.; ZhangM.; YanF.;

  • 作者单位

    Department of Radiology Second Affiliated Hospital Zhejiang University Hangzhou 310009 China;

    Department of Radiology Second Affiliated Hospital Zhejiang University Hangzhou 310009 China;

    Department of Radiology Second Affiliated Hospital Zhejiang University Hangzhou 310009 China;

    Department of Radiology Second Affiliated Hospital Zhejiang University Hangzhou 310009 China;

    Department of Radiology Second Affiliated Hospital Zhejiang University Hangzhou 310009 China;

    Department of Radiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Chronic kidney disease; Diffusion-weighted imaging; Pathology;

    机译：慢性肾病;扩散加权成像;病理学;

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