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首页> 外文期刊>European geriatric medicine. >P-686: Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults (MAPT Study)
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P-686: Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults (MAPT Study)

机译：P-686：C-反应蛋白和同型素浓度在社区住宅年龄较大的成年人（MAPT学习）中的5年间随访中，C-反应蛋白和同型素浓度的痛苦

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Introduction: This study aimed to analyze if low-grade inflammation (LGI) (chronically raised C-reactive protein—CRP) and hyperho-mocysteinemia (HHcy) were associated with variation in intrinsic capacity (IC) domains (mobility, cognition, psychological and vitality) and in a combined IC Z-score over a 5-year follow-up among non-demented, community-dwelling older adults. Methods: Data from 1516 subjects (64.5% female, mean age 75.4 years, SD = 4.5), volunteers from the interventional study Multidomain Alzheimer Preventive Trial (MAPT). Plasma CRP (at baseline, 6 and 12 months) and homocysteine (at baseline) concentrations were measured. LGI was defined as having ≥ 2 consecutively CRP readings > 3 to 10 mg/L between baseline and 12 months, and HHcy was defined as homocysteine > 15μM/L. IC domains were operationalized as follows: Psychological. Depressive symptoms evaluated by the Geriatric Depression Scale (GDS); Mobility. Assessed by the Short Physical Performance Battery (SPPB); Cognitive function. Examined by a Z-score combining four tests; Vitality. Based on hand grip strength. Outcomes were combined into a composite IC Z-score. Results: IC Z-score decreased among groups with no inflammation and LGI after 5 years, but this decrease was more pronounced among the LGI group (unadjusted mean group difference: 0.09, 95% CI: 0.01 to 0.16; p = 0.032). Participants with hyperhomocysteinemia also presented IC Z-score decreases over time. Combined conditions provided more pronounced declines, even after adjusting for potential confounders. Conclusions: LGI (based on persistently high CRP concentrations) and hyperhomocysteinemia were both related with impairment on the combined IC levels among older adults after a 5-year follow-up.
机译：介绍：本研究旨在分析低级炎症（LGI）（慢性升高的C-反应蛋白-CRP）和HHCO-硫氰酸血症（HHCY）与内在能力（IC）结构域的变异有关（移动，认知，心理和活力）和在非痴呆，社区住宅年龄大成年人中，在综合IC Z-Score超过5年的随访中。方法：来自1516名科目的数据（女性64.5％，平均75.4岁，SD = 4.5），来自介入研究多麦草Alzheimer预防性试验（MAPT）的志愿者。测量血浆CRP（在基线，6和12个月）和同型半胱氨酸（基线）浓度。 LGI被定义为在基线和12个月之间具有≥2的连续CRP读数> 3至10mg / L，并且Hhcy定义为同型半胱氨酸>15μm/升。 IC域名是如下的运作：心理。抑郁症状由老年抑郁症评估（GDS）评估;移动性。通过短的物理性能电池（SPPB）进行评估;认知功能。通过Z分数组合四个测试来检查;活力。基于手动握力。结果被组合成复合IC Z分数。结果：5年后没有炎症和LGI的群体中的IC Z-得分减少，但LGI组中的减少更加明显（未调整的平均群体差：0.09,95％：0.01至0.16; P = 0.032）。 Hyperhomysteinemia的参与者也随着时间的推移呈现IC Z-Score降低。结合条件提供了更明显的下降，即使在调整潜在的混乱后也是如此。结论：LGI（基于持续高CRP浓度）和高管抑制症既与5年后成年人合并的IC水平的损害均为损害。

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