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首页> 外文期刊>European archives of psychiatry and clinical neuroscience >QTc prolongation in short-term treatment of schizophrenia patients: effects of different antipsychotics and genetic factors
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QTc prolongation in short-term treatment of schizophrenia patients: effects of different antipsychotics and genetic factors

机译：精神分症患者短期治疗QTC延长：不同抗精神病药和遗传因素的影响

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Antipsychotics are effective in treating schizophrenia but may lead to a higher cardiovascular risk due to QTc prolongation. Besides drugs, genetic and clinical factors may contribute to QTc prolongation. The aim of this study is to examine the effect of candidate genes known for QTc prolongation and their interaction with common antipsychotics. Thus, 199 patients were genotyped for nine polymorphisms in KCNQ1, KCNH2, SCN5A, LOC10537879, LOC101927066, NOS1AP and NUBPL. QTc interval duration was measured before treatment and weekly for 5 weeks while being treated with risperidone, quetiapine, olanzapine, amisulpride, aripiprazole and haloperidol in monotherapy. Antipsychotics used in this study showed a different potential to affect the QTc interval. We found no association between KCNH2, KCNQ1, LOC10537879, LOC101927066, NOS1AP and NUBPL polymorphisms and QTc duration at baseline and during antipsychotic treatment. Mixed general models showed a significant overall influence of SCN5A (H558R) on QTc duration but no significant interaction with antipsychotic treatment. Our results do not provide evidence for an involvement of candidate genes for QTc duration in the pathophysiology of QTc prolongation by antipsychotics during short-term treatment. Further association studies are needed to confirm our findings. With a better understanding of these interactions the cardiovascular risk of patients may be decreased.
机译：抗精神病药有效治疗精神分裂症，但由于QTC延长，可能导致更高的心血管风险。除了药物，遗传和临床因素也可能导致QTC延长。本研究的目的是检测QTC延长所知的候选基因及其与常见抗精神病学的相互作用的影响。因此，199例患者在KCNQ1，KCNH2，SCN5A，LOM10537879，LOM11927066，NOS1AP和NUBPL中进行九种多态性进行基因分型。 QTC间隔持续时间在治疗前和每周5周的时间测量，同时用Risperidone，Quetiapine，奥氮藻，氨基丙酮，氨基吡唑和氟哌啶醇在单疗法中处理。本研究中使用的抗精神病药有一种影响QTC间隔的潜力。我们在KCNH2，KCNQ1，LOM10537879，LOM11927066，NOS1AP和NUBPL多态性和基线期间的QTC持续时间和抗精神病药治疗中没有关联。混合一般模型显示SCN5A（H558R）对QTC持续时间的显着影响，但与抗抗精神病治疗没有显着的相互作用。我们的结果不提供候选基因在短期治疗期间通过抗精神病药在QTC延长的病理生理学中涉及候选基因的证据。需要进一步的关联研究来确认我们的研究结果。通过更好地理解这些相互作用，患者的心血管风险可能会降低。

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