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首页> 外文期刊>Immunology, endocrine & metabolic agents in medicinal chemistry. >Suppression of Arthritis Progression with Lutein Extracted from Tagetes erecta in Collagen-Induced Arthritis Model Rats
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Suppression of Arthritis Progression with Lutein Extracted from Tagetes erecta in Collagen-Induced Arthritis Model Rats

机译：用叶氏菌勃起的关节炎模型大鼠Tagetes erecta提取的叶黄素抑制关节炎进展

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Background: Chronic arthralgia and arthritis are the most common causes of activity limitation and disability among middle-aged and older adults. Rheumatoid arthritis is a persistent inflammation of the synovium of the joints, leading to destruction of the surrounding bone and cartilage and ultimately joint de formities. Several studies reported that carotenoid intake, including lutein, was associated with a decreased risk of rheumatoid arthritis. We examined the effects of lutein extract (LE) from Tagetes erecta on inflammatory suppression in the collagen-induced arthritis (CIA) model rat.Method: CIA model rats were induced by injection of emulsion containing bovine type II collagen and Freund's incomplete adjuvant to DA/slc male rats. The study was designed with four experimental groups referred to as: normal, vehicle, ibuprofen (30 mg/kg) and LE (1.5 mg/kg). Test substances were administrated orally after immunization for 31 days every day.Results: Arthritis scores and paw swelling were significantly suppressed by LE or ibuprofen administration. Histopathological analysis showed that LE suppressed synovial fibro-blast proliferation, plasma cell accumulation, pannus formation and new bone formation in the hind paw, although no changes in inflammation and cartilage metabolism biomarkers in plasma were detected after LE administration. Furthermore, proliferation of rabbit synovial cells (HIG-82) was inhibited by the addition of lutein.Conclusion: We provide direct evidence that lutein suppresses inflammation in the collagen-induced arthritis model rat. It is expected that lutein may play a beneficial role in rheumatoid arthritis.
机译：背景：慢性关节痛和关节炎是中年和老年人之间活动限制和残疾的最常见原因。类风湿性关节炎是关节臂悬浮症的持续炎症，导致周围的骨和软骨和最终联合的形状。几项研究报告说，包括叶黄素在内的类胡萝卜素摄入量与类风湿性关节炎的风险降低有关。我们研究了叶黄素提取物（Le）从Tagetes erecta对胶原诱导的关节炎（CIA）模型鼠标炎症抑制的影响。方法：CIA模型大鼠通过注射含牛II型胶原蛋白和弗氏不完全佐剂的乳液诱导/ SLC雄性大鼠。该研究设计有四个实验组：正常，载体，布洛芬（30mg / kg）和Le（1.5mg / kg）。每天在免疫31天后口服测试物质。结果：由Le或布洛芬施用显着抑制关节炎分数和爪子肿胀。组织病理学分析表明，LE抑制了滑膜纤维增殖，血浆细胞积累，豆类形成和新骨质形成，尽管在Le给药后检测到血浆中炎症和软骨代谢生物标志物的变化。此外，通过加入叶黄素抑制兔滑膜细胞（HIG-82）的增殖。结论：我们提供直接证据，即叶黄素抑制胶原诱导的关节炎模型大鼠中的炎症。预计叶黄素可能在类风湿性关节炎中发挥有益作用。

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