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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Infectious processes and systemic lupus erythematosus
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Infectious processes and systemic lupus erythematosus

机译：传染性过程和系统性狼疮红斑狼疮

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Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding of the interactions between infectious agents and the host, explaining the interest in gathering updated scientific information on this topic. According to the literature, the pathogens most frequently associated with SLE are viruses, notably human endogenous retroviruses, Epstein-Barr virus, parvovirus B19, cytomegalovirus and human immunodeficiency virus type 1, alongside certain bacterial components that can also trigger activation of the immune system. The mechanisms underlying autoreactivity remain unclear but various explanations have been proposed, including immunological changes responsible for infectious processes or molecular mimicry between host structures and those of infectious agents.
机译：Systemic Lupus红斑（SLE）是一种自身免疫性慢性炎症性疾病未知病因，尽管遗传和环境因素似乎有助于其发病机制。具体地，感染过程与SLE发作和加剧相关。但是，我们远非完全了解传染性代理人与主人之间的相互作用，解释了对该主题收集更新的科学信息的兴趣。根据文献，最常与SLE相关的病原体是病毒，特别是人类内源性逆转录病毒，Epstein-Barr病毒，Parvovirus B19，细胞瘤病毒和人免疫缺陷病毒型1型，以及某些细菌组分，也可以引发免疫系统的激活。基础自身反应性的机制仍然尚不清楚，但已经提出了各种解释，包括负责宿主结构与传染性药剂之间的传染性过程或分子模拟的免疫变化。

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