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首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Evaluating antidisease immunity to malaria and implications for vaccine design
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Evaluating antidisease immunity to malaria and implications for vaccine design

机译：评估疟疾抗疟疾抗疟疾和疫苗设计的影响

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Summary Immunity to malaria could be categorized broadly as antiparasite or antidisease immunity. While most vaccine research efforts have focused on antiparasite immunity, the evidence from endemic populations suggest that antidisease immunity is an important component of natural immunity to malaria. The processes that mediate antidisease immunity have, however, attracted little to no attention, and most interests have been directed towards the antibody responses. This review evaluates the evidence for antidisease immunity in endemic areas and discusses the possible mechanisms responsible for it. Given the key role that inflammation plays in the pathogenesis of malaria, regulation of the inflammatory response appears to be a major mechanism for antidisease immunity in naturally exposed individuals.
机译：总结疟疾的免疫可以广泛分类为抗抗原或反敏感性免疫。 虽然大多数疫苗研究努力重点关注抗哌酸盐免疫力，但具有流动性群体的证据表明，抗敏感性免疫是对疟疾自然免疫的重要组成部分。 然而，介导反向酶免疫的过程吸引了很少的注意，没有注意，大多数利益都针对抗体反应。 该审查评估了流行区域抗敏酶免疫力的证据，并讨论了对其负责的可能机制。 鉴于炎症在疟疾发病机制中发挥炎症的关键作用，炎症反应的调节似乎是天然暴露的个体中抗敏感性免疫的主要机制。

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