...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Immunology: An Official Journal of the British Society for Immunology >Adaptive immune education by gut microbiota antigens
【24h】

Adaptive immune education by gut microbiota antigens

机译：肠道微生物脂肪剂的适应性免疫教育

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Host-microbiota mutualism has been established during long-term co-evolution. A diverse and rich gut microbiota plays an essential role in the development and maturation of the host immune system. Education of the adaptive immune compartment by gut microbiota antigens is important in establishing immune balance. In particular, a critical time frame immediately after birth provides a 'window of opportunity' for the development of lymphoid structures, differentiation and maturation of T and B cells and, most importantly, establishment of immune tolerance to gut commensals. Depending on the colonization niche, antigen type and metabolic property of different gut microbes, CD4 T-cell responses vary greatly, which results in differentiation into distinct subsets. As a consequence, certain bacteria elicit effector-like immune responses by promoting the production of pro-inflammatory cytokines such as interferon-gamma and interleukin-17A, whereas other bacteria favour the generation of regulatory CD4 T cells and provide help with gut homeostasis. The microbiota have profound effects on B cells also. Gut microbial exposure leads to a continuous diversification of B-cell repertoire and the production of T-dependent and -independent antibodies, especially IgA. These combined effects of the gut microbes provide an elegant educational process to the adaptive immune network. Contrariwise, failure of this process results in a reduced homeostasis with the gut microbiota, and an increased susceptibility to various immune disorders, both inside and outside the gut. With more definitive microbial-immune relations waiting to be discovered, modulation of the host gut microbiota has a promising future for disease intervention.
机译：在长期共同进化期间建立了宿主微生物群互动。多种多样的肠道微生物群在宿主免疫系统的开发和成熟中起着重要作用。通过肠道微生物A抗原的自适应免疫隔室的教育对于建立免疫平衡很重要。特别是，出生后立即的关键时间框为开发淋巴结结构，T和B细胞的淋巴结结构，分化和成熟，以及最重要的是，为肠道共生建立免疫耐受性的“机会窗口”。取决于不同肠道微生物的抗殖度，抗原型和代谢性，CD4 T细胞应答大大变化，这导致分化为不同的子集。因此，某些细菌通过促进促炎细胞因子如干扰素-γ-17A的产生，而其他细菌引发效应的免疫反应，而其他细菌有利于调节CD4 T细胞的产生，并提供肠道稳态的帮助。 Microbiota也对B细胞产生了深远的影响。肠道微生物暴露导致B细胞曲目的连续多样化以及依赖于依赖性和依赖性抗体，特别是IgA的产生。肠道微生物的这些组合效果为自适应免疫网络提供了优雅的教育过程。相比之下，该过程的失败导致肠道微生物肿瘤减少的稳态，以及对肠内内外的各种免疫紊乱的易感性增加。随着更明确的微生物 - 免疫关系等待被发现，宿主细胞微生物群的调节具有疾病干预的有希望的未来。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号