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首页> 外文期刊>European journal of epidemiology >Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
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Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

机译：LifeLines下一篇：一个潜在的出生队列将下一代添加到三代救生员队列研究

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Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1?year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials—including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine—will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.
机译：流行病学研究表明，先进，产前，出生和早期因素与终身健康之间存在良好的关系。 LifeLines接下来是一个出生队列，旨在研究一个四代设计中的内在和外在决定因素对健康和疾病的影响。它嵌入了生活中的队列研究中，这是一个潜在的三代人口的队列研究，记录了居住在荷兰北部的167,729人的健康和健康相关方面。在Lifelines下，我们的目标是包括1500名怀孕的救生员参与者，并在出生后至少1岁之前，他们的合作伙伴和孩子持续到至少1岁。然后，在生活中的程序下嵌入身体和心理健康的长期随访。在LifeLines期间，下一步研究期间生物材料 - 包括孕产妇和新生儿（脐带）血液，胎盘组织，粪便，母乳，鼻拭子和尿液 - 将在10个时间点从母亲和儿童收集。我们还将通过连接设备的14个不同的时间点和连续数据来收集关于医疗，社会，生活方式和环境因素的数据。怀孕期间的母亲和儿童的广泛集合来自母亲和儿童，然后提供将包括母亲和新生儿微生物组合物的环境因素（EPI）遗传，健康和发育成果联系起来。生活中的研究嵌套使我们能够包括先进的转基因数据，可用于识别群组内的其他大家庭。

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