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首页> 外文期刊>European journal of pharmaceutical sciences >Research on 5-fluorouracil as a drug carrier materials with its in vitro release properties on organic modified magadiite
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Research on 5-fluorouracil as a drug carrier materials with its in vitro release properties on organic modified magadiite

机译：用其在有机改性的木酰基碳酸盐上的5-氟尿嘧啶作为药物载体材料的研究

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摘要

The magadiite (MAG) was modified by cetyltrimethyl ammonium-Bromide (CTAB) and then further modified by Chitosan (CS) which is called organic modified-magadiite as magadiite-cetyltrimethyl ammonium bromide (MAG-CTAB) and magadiite-cetyltrimethyl ammonium bromide-Chitosan (MAG-CTAB-CS), respectively, in this research study. The MAG, MAG-CTAB, and MAG-CTAB-CS were used as 5-Fluorouracil (5-FU) drug carrier materials; the drug carrier's materials were marked as magadiite-5-Fluorouracil (MAG/5-FU), magadiite-cetyltrimethyl ammonium bromide-5-Fluorouracil (MAG-CTAB/5-FU), and magadiite-cetyltrimethyl ammonium bromide-Chitosan (MAG-CTAB-CS/5-FU). X-ray diffraction(XRD, Flourier transform infrared spectrometry (FTIR) and scanning electron microscopy (SEM) results were shown that 5-Fluorouracil was combined with carrier materials through physical apparent adsorption, ion exchange, chemical bond, hydrogen bond, and electrostatic interaction. The drug carriers in vitro release behavior in simulated gastric fluids (SGF, pH = 1.35) and intestinal fluids (SIF, pH = 7.40) were investigated. The drug loading capacity and accumulated release ration were as follows the order: MAG-CTAB-CS/5-FU MAG-CTAB/5-FU MAG/5-FU. The drug loading capacity of MAG-CTAB-CS/5-FU was 162.29 mg/g, 48 h later the drug accumulated release ratio was 61.24%, and the release amount was 97.52 mg/g for 24 h. Korsmeyer-Peppas model and First order model were found to be suitable to describe the vitro release behavior of 5-Fluorouracil. This would be an economically viable and efficient method for the preparation of advanced drug delivery system.
机译：通过十六烷基甲基溴化铵（CTAB）来改性MagaDiite（Mag），然后通过壳聚糖（Cs）进一步改性，所述壳聚糖（Cs）称为有机改性 - 木酰亚胺氨基铵（Mag-ctab）和木酰基 - 甲基三甲基铵溴化物 - 壳聚糖（Mag-CTAB-CS）分别在本研究研究中。 Mag，Mag-ctab和Mag-ctab-Cs用作5-氟尿嘧啶（5-FU）药物载体材料;药物载体的材料标记为木酰胺-5-氟尿嘧啶（MAG / 5-FU），金刚石 - 甲基三甲基铵（Mag-CTAB / 5-FU）和木酰亚胺 - 甲基三甲基铵（Mag-） - 壳聚糖（Mag- CTAB-CS / 5-FU）。显示X射线衍射（XRD，较易转换红外光谱（FTIR）和扫描电子显微镜（SEM）结果，通过物理表观吸附，离子交换，化学键，氢键和静电相互作用将5-氟尿嘧啶与载体材料合并。研究了模拟胃液中的体外释放行为（SGF，pH = 1.35）和肠液（SIF，pH = 7.40）的药物载体。药物负载能力和累积释放配量如下所述：MAG-CTAB- CS / 5-FU＆GT; MAG-CTAB / 5-FU＆GT; MAG / 5-FU。MAG-CTAB-CS / 5-FU的药物负载能力为162.29 mg / g，48小时以后的药物累积释放比为61.24％，释放量为97.52mg / g 24小时。发现Korsmeyer-Peppas模型和第一阶模型适合描述5-氟尿嘧啶的体外释放行为。这将是一种经济上可行和有效的方法用于制备先进的药物递送系统。

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    Ge Mingliang; Tang Wei; Du Mingyi; Liang Guodong; Hu Guoqing; Alam Jahangir S. M.;

  • 作者单位

    South China Univ Technol Key Lab Polymer Proc Engn Natl Engn Res Ctr Novel Equipment Polymer Proc;

    South China Univ Technol Key Lab Polymer Proc Engn Natl Engn Res Ctr Novel Equipment Polymer Proc;

    South China Univ Technol Key Lab Polymer Proc Engn Natl Engn Res Ctr Novel Equipment Polymer Proc;

    Sun Yat Sen Univ Key Lab Polymer Composite &

    Funct Mat Minist Educ Guangzhou 510275 Guangdong;

    South China Univ Technol Key Lab Polymer Proc Engn Natl Engn Res Ctr Novel Equipment Polymer Proc;

    South China Univ Technol Key Lab Polymer Proc Engn Natl Engn Res Ctr Novel Equipment Polymer Proc;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Magadiite; Chitosan; 5-fluorouracil; Drug delivery system;

    机译：木马;壳聚糖;5-氟尿嘧啶;药物递送系统;

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