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首页> 外文期刊>European thyroid journal >Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature
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Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature

机译：血清miRNA作为甲状腺癌诊断和预后的生物标志物：对文献进行全面审查

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摘要

Background/Objectives: Thyroid cancer is the most common endocrine malignancy and accounts for 1 % of cancers. In recent years, there has been much interest in the feasibility of using miRNAs or miRNA panels as biomarkers for the diagnosis of thyroid cancer. miRNAs are noncoding RNAs with 21-23 nucleotides that are highly conserved during evolution. They have been proposed as regulators of gene expression, apoptosis, cancer, and cell growth and differentiation. Methods: The Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO), and Web of Science were searched. Results: The serum level of miRNAs (miRNA-375, 34a, 145b, 221, 222, 155, Let-7, 181b) can be used as molecular markers for the diagnosis and prognosis of thyroid cancer in the serum samples of patients with thyroid glands.
机译：背景/目标：甲状腺癌是最常见的内分泌恶性肿瘤，占1％的癌症。 近年来，对使用miRNA或miRNA面板作为生物标志物进行诊断的甲状腺癌的生物标志物的可行性有很多兴趣。 miRNA是非沉积的RNA，其具有21-23个核苷酸，其在进化期间高度保守。 他们已被提出作为基因表达，细胞凋亡，癌症和细胞生长和分化的调节因素。 方法：搜查了开放访问期刊（DOAJ），谷歌学者，PubMed（NLM），Lista（EBSCO）和科学网站的目录。 结果：miRNA的血清水平（miRNA-375,34a，145b，221,222,55，let-7,181b）可用作分子标志物中甲状腺患者血清样本中甲状腺癌的诊断和预后的分子标记 腺体。

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