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首页> 外文期刊>European journal of preventive cardiology >Assessment of peripheral endothelial function predicts future risk of solid-tumor cancer
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Assessment of peripheral endothelial function predicts future risk of solid-tumor cancer

机译：外周内皮功能评估预测固体肿瘤癌的未来风险

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Aims Cardiovascular health metrics predict the risk not only of cardiovascular diseases but also of several types of cancers. Microvascular endothelial dysfunction can predict future cardiovascular adverse events, but the predictive value of microvascular endothelial dysfunction for future risk of solid-tumor cancer has not been characterized. Methods A total of 488 patients who underwent microvascular endothelial function assessment using reactive hyperemia peripheral arterial tonometry were included in this study. Microvascular endothelial dysfunction was defined as a reactive hyperemia peripheral arterial tonometry index 2.0, 10 patients (3.7%) were diagnosed with incident solid-tumor cancer during follow-up (p = 0.009). Patients with a reactive hyperemia peripheral arterial tonometry index 2.0 (log-rank p = 0.017) (median follow-up 6.0 (3.0-9.1) years). Cox proportional hazard analyses showed that a reactive hyperemia peripheral arterial tonometry index 30 kg/m(2), 2.79 (95% confidence interval 1.21-6.41; p = 0.016) after adjusting for fasting plasma glucose, systolic blood pressure, smoking status (current or former), and body mass index, and 2.43 (95% confidence interval 1.10-5.34; p = 0.028) after adjusting for Framingham risk score. Conclusion Microvascular endothelial dysfunction, as defined by a reactive hyperemia peripheral arterial tonometry index <= 2.0, was associated with a greater than two-fold increased risk of solid-tumor cancer. Microvascular endothelial dysfunction may be a useful marker to predict the future risk of solid-tumor cancer, in addition to its known ability to predict cardiovascular disease. Further research is necessary to develop adequate cancer screening strategies for patients with microvascular endothelial dysfunction.
机译：AIMS心血管健康指标预测不仅具有若干类型的癌症的心血管疾病的风险。微血管内皮功能障碍可以预测未来的心血管不良事件，但微血管内皮功能障碍的预测值尚未表征未来固体肿瘤癌的风险。方法本研究纳入了使用反应性充血周围动脉仪进行的488例接受微血管内皮功能评估的患者。微血管内皮功能障碍定义为反应性充血周围动脉肾功能术指数2.0，在随访期间被诊断出入射的固体肿瘤癌（P = 0.009）。患者反应性充血周围动脉矫形器指数2.0（对秩P = 0.017）（中位出现后6.0（3.0-9.1）年）。 Cox比例危害分析表明，在调整空腹血糖，收缩压，吸烟状态（电流的收缩压或以前的）和体重指数，在调整Framingham风险评分后，体重指数和2.43（95％置信区间1.10-5.34; p = 0.028）。结论微血管内皮功能障碍，如反应性充血周围动脉曲目指数<= 2.0所定义，与高于两倍的固体肿瘤癌风险相关。除了预测心血管疾病的已知能力之外，微血管内皮功能障碍可能是预测固体肿瘤癌的未来风险。进一步的研究是为微血管内皮功能障碍患者制定适当的癌症筛查策略。

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