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首页> 外文期刊>European journal of preventive cardiology >Predictors of response to exercise training in patients with coronary artery disease - a subanalysis of the SAINTEX-CAD study
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Predictors of response to exercise training in patients with coronary artery disease - a subanalysis of the SAINTEX-CAD study

机译：冠状动脉疾病患者运动培训的反应预测因子 - Saintex-CAD研究的细胞分析

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Exercise training improves peak oxygen uptake, an important predictor of mortality in coronary artery disease patients. The influence of clinical and disease characteristics on training response is not well established in coronary artery disease. Therefore, we aimed to evaluate whether baseline cardiovascular disease variables and training intensity can predict the maximal aerobic response to exercise training. The Study on Aerobic INTerval EXercise training in coronary artery disease patients (SAINTEX-CAD) previously showed that 12 weeks of aerobic interval training and continuous training equally improved peak oxygen uptake in coronary artery disease patients. We identified 24 exercise non-responders (change peak oxygen uptake <1 ml/kg/min) among 167 participants in SAINTEX-CAD. In a between-group comparison, exercise non-responders were older, their baseline peak oxygen uptake and oxygen uptake efficiency slope were higher, and exercise non-responders were more frequently included after elective percutaneous coronary intervention (all p < 0.05). In multiple logistic regression analysis, age (odds ratio = 1.11 (1.04-1.18), p = 0.001), history of elective percutaneous coronary intervention (odds ratio = 3.31 (1.12-9.76), p = 0.030) and higher baseline peak oxygen uptake (odds ratio = 1.16 (1.06-1.27), p = 0.001) were independent predictors of exercise non-response. In multiple linear regression analysis, age (ss = -0.605, p = 0.001), history of elective percutaneous coronary intervention (ss = -15.401, p = 0.010), training intensity (ss=0.447, p = 0.008), baseline physical activity (ss=0.014, p = 0.003) and oxygen uptake efficiency slope (ss = -0.014, p < 0.001) predicted percentage change in peak oxygen uptake and explained 41% of the variability in percentage change in peak oxygen uptake. To summarize, 14% of coronary artery disease patients were exercise non-responders. Higher baseline peak oxygen uptake and oxygen uptake efficiency slope, history of elective percutaneous coronary intervention, older age, lower training intensity and lower baseline physical activity were predictors of training non-response. Identification of patients with a large likelihood of non-response is a first step towards patient tailored exercise programmes.
机译：运动培训改善了冠状动脉疾病患者死亡率的重要预测因子。冠状动脉疾病患者临床和疾病特征对训练反应的影响。因此，我们旨在评估基线心血管疾病变量和训练强度是否可以预测运动训练的最大好氧反应。冠状动脉疾病患者有氧间隔运动训练研究（Saintex-CAD）先前表明，有氧间隔训练12周和连续训练同样提高冠状动脉疾病患者的峰值氧气吸收。我们在Saintex-CAD的167名参与者中鉴定了24项运动非响应者（改变峰氧吸收<1ml / kg / min）。在一组比较中，运动非响应者年龄较大，它们的基线峰氧吸收和氧吸收效率坡度较高，并且在选修经皮冠状动脉干预后更常用的运动非响应者（所有P <0.05）。在多元逻辑回归分析中，年龄（差距= 1.11（1.04-1.18），P = 0.001），选修历史的经皮冠状动脉介入（差距= 3.31（1.12-9.76），P = 0.030）和更高的基线峰氧气吸收（赔率比= 1.16（1.06-1.27），P = 0.001）是运动不反应的独立预测因子。在多元线性回归分析中，年龄（SS = -0.605，P = 0.001），选修历史的精神经审冠状动脉介入（SS = -15.401，P = 0.010），训练强度（SS = 0.447，P = 0.008），基线身体活动（SS = 0.014，p = 0.003）和氧吸收效率斜率（SS = -0.014，P <0.001）预测峰值氧吸收的百分比变化，并解释了41％的峰值氧摄取百分比变化的变化。总而言之，14％的冠状动脉疾病患者是运动非响应者。较高的基线峰氧吸收和氧气吸收效率坡，选修历史的经皮冠状动脉介入，年龄较大，培训强度和较低的基线身体活动是训练不反应的预测因子。鉴定较大的非反应可能性的患者是患者量身定制的运动计划的第一步。

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