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首页> 外文期刊>European journal of preventive cardiology >Sex-specific clinical outcomes of impaired glucose status: A long follow-up from the Tehran Lipid and Glucose Study
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Sex-specific clinical outcomes of impaired glucose status: A long follow-up from the Tehran Lipid and Glucose Study

机译：葡萄糖状况受损的性别特异性临床结果：来自德黑兰脂质和葡萄糖研究的长期随访

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Aims To investigate the sex-specific associations of prediabetes with major clinical outcomes including incident type 2 diabetes, chronic kidney disease, hypertension, coronary heart disease, stroke and all-cause mortality. Methods Among 8498 Iranian adults from the Tehran Lipid and Glucose Study, aged >= 30 years and without diagnosed type 2 diabetes, gender-interactions were assessed for each outcome, followed by sex-separated multivariate-adjusted Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs) of different prediabetes categories, including impaired fasting glucose (IFG), defined by the American Diabetes Association (ADA) and World Health Organization (WHO), as fasting plasma glucose of 5.6-6.9 mmol/L and 6.1-6.9 mmol/L, respectively, and impaired glucose tolerance, defined as 2-h post challenge plasma glucose of 7.8-11 mmol/L. Results Sex-specific associations existed for men between IFG-ADA and chronic kidney disease (hazard ratio: 1.28, 95% CI 0.99-1.65; p(interaction) = 0.008) and between IFG-WHO and stroke (hazard ratio: 2.15, 95% CI 1.08-4.27; p(interaction) = 0.21); and for women between IFG-ADA and hypertension (hazard ratio: 1.24, 95% CI 1.04-1.48; p(interaction) = 0.06) and between impaired glucose tolerance and coronary heart disease (hazard ratio: 1.57, 95% CI 1.14-2.16; p(interaction) = 0.05). Among both genders, all prediabetes definitions were associated with type 2 diabetes but none with mortality. Conclusions The hazards of prediabetes definitions may differ between genders depending on the outcome of interest. IFG-WHO among men and impaired glucose tolerance among women are particularly important because of their association with incident stroke and coronary heart disease, respectively. Considering these sex differences could improve personalized management of prediabetes.
机译：旨在调查预先审查Prediabetes的性别特定协会，主要临床结果，包括事件2型糖尿病，慢性肾病，高血压，冠心病，中风和全导致死亡率。方法在德黑兰脂和葡萄糖研究中的8498名伊朗成年人中，年龄> = 30年​​且未诊断出2型糖尿病，对每种结果进行评估性别相互作用，其次是性分离的多变量调整的Cox比例危险模型来计算危险比95％的不同预测分类（CIS）的置信区间（CIS）包括禁止的空腹葡萄糖（IFG），由美国糖尿病协会（ADA）和世界卫生组织（世卫组织）定义，作为5.6-6.9mmol / L的空腹血浆葡萄糖。 6.1-6.9 mmol / l，分别和葡萄糖耐量受损，定义为7.8-11mmol / l的肉体葡萄糖的2-h后。结果为IFG-ADA和慢性肾病（危害比率：1.28,95％CI 0.99-1.65; P（相互作用）= 0.008）和IFG-WHO和中风（危险比：2.15,95 ％CI 1.08-4.27; p（相互作用）= 0.21）;和IFG-ADA和高血压之间的女性（危害比率：1.24,95％CI 1.04-1.48; P（相互作用）= 0.06），葡萄糖耐量损害和冠心病（危险比：1.57,95％CI 1.14-2.16） ; p（相互作用）= 0.05）。在两者中，所有PrediaBetes定义都与2型糖尿病有关，但没有死亡率。结论，预先审查定义的危害取决于感兴趣的结果。 IFG-谁在男性中，女性之间的葡萄糖耐受性分别与事故卒中和冠心病的关联尤其重要。考虑这些性别差异可以改善预先审查的个性化管理。

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