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首页> 外文期刊>European Polymer Journal >Assessments of polycaprolactone/hydroxyapatite composite scaffold with enhanced biomimetic mineralization by exposure to hydroxyapatite via a 3D-printing system and alkaline erosion
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Assessments of polycaprolactone/hydroxyapatite composite scaffold with enhanced biomimetic mineralization by exposure to hydroxyapatite via a 3D-printing system and alkaline erosion

机译：通过3D印刷系统暴露于羟基磷灰石和碱性侵蚀，通过暴露于羟基磷灰石的增强仿生矿化的聚己内酯/羟基磷灰石复合支架的评估

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摘要

In the 3D-printed polycaprolactone/hydroxyapatite composite scaffold, hydroxyapatite particles are usually covered by a thin-film of polycaprolactone because of the rheological characteristics of the extrusion process. This phenomenon could disrupt the original bioactive characteristics of hydroxyapatite particles. In this study, to expose the hydroxyapatite particles covered by a thin-film of polycaprolactone, an alkaline erosion method was proposed. Moreover, to investigate the cell activity and biomimetic mineralization influenced by hydroxyapatite exposure, polycaprolactone scaffolds, polycaprolactone scaffolds with alkaline erosion, and polycaprolactone/ hydroxyapatite scaffolds were fabricated as control groups and compared with the polycaprolactone/hydroxyapatite scaffolds with alkaline erosion. Furthermore, to characterize the 3D-printed composite scaffold in terms of hydroxyapatite exposure, several assessments were made including morphology, pore size, porosity, mechanical compressive modulus, surface roughness, water absorption. Consequently, the proposed alkaline erosion for hydroxyapatite particle exposure had little effect on the structure of the fabricated scaffolds via the 3D-printing system including the designed pore size, porosity, and mechanical properties. Moreover, mechanical properties of the polycaprolactone/hydroxyapatite scaffolds were increased by the high dispersion of hydroxyapatite in the polycaprolactone matrix. Additionally, we verified that the exposure of hydroxyapatite particles by alkaline erosion improves cell proliferation and biomimetic mineralization, because calcium and phosphate ions were rapidly deposited on the scaffold.
机译：在3D印刷的聚己内酯/羟基磷灰石复合支架中，羟基磷灰石颗粒通常由聚己内酯的薄膜覆盖，因为挤出过程的流变特性。这种现象可能破坏羟基磷灰石颗粒的原始生物活性特性。在该研究中，为了暴露由聚己内酯薄膜覆盖的羟基磷灰石颗粒，提出了一种碱性腐蚀方法。此外，为了研究受羟基磷灰石暴露影响的细胞活性和仿生矿化，聚己内酯支架，具有碱性腐蚀的聚己内酯支架，以及聚己内酯/羟基磷灰石支架作为对照组，并与碱性腐蚀的聚己内酯/羟基磷灰石支架进行比较。此外，为了在羟基磷灰石暴露方面表征3D印刷复合支架，制备了几种评估，包括形态，孔径，孔隙率，机械压缩模量，表面粗糙度，吸水性。因此，提出的羟基磷灰石颗粒暴露的碱性腐蚀对通过包括设计的孔径，孔隙率和机械性能的3D印刷系统对制造的支架的结构几乎没有影响。此外，通过聚己内酯基质中羟基磷灰石的高分散体增加了聚己内酯/羟基磷灰石支架的机械性能。此外，我们核实羟基磷灰石颗粒通过碱性腐蚀的暴露改善了细胞增殖和仿生矿化，因为钙和磷酸盐离子在支架上迅速沉积。

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