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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The fabrication of well‐interconnected polycaprolactone/hydroxyapatite composite scaffolds, enhancing the exposure of hydroxyapatite using the wire‐network molding technique
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The fabrication of well‐interconnected polycaprolactone/hydroxyapatite composite scaffolds, enhancing the exposure of hydroxyapatite using the wire‐network molding technique

机译：互联聚己内酯/羟基磷灰石复合支架的制造，使用线网络模塑技术增强羟基磷灰石的暴露

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Abstract In this study, the fabrication method was proposed for the well‐interconnected polycaprolactone/hydroxyapatite composite scaffold with exposed hydroxyapatite using modified WNM technique. To characterize well‐interconnected scaffolds in terms of hydroxyapatite exposure, several assessments were performed as follows: morphology, mechanical property, wettability, calcium ion release, and cell response assessments. The results of these assessments were compared with those of control scaffolds which were fabricated by precision extruding deposition (PED) apparatus. The control PED scaffolds have interconnected pores with nonexposed hydroxyapatite. Consequently, cell attachment of proposed WNM scaffold was improved by increased hydrophilicity and surface roughness of scaffold surface resulting from the exposure of hydroxyapatite particles and fabrication process using powders. Moreover, cell proliferation and differentiation of WNM scaffold were increased, because the exposure of hydroxyapatite particles may enhance cell adhesion and calcium ion release. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2315–2325, 2017.
机译：摘要在本研究中，使用改性的WNM技术提出了具有暴露的羟基磷灰石的良好互连的聚己内酯/羟基磷灰石复合支架的制造方法。为了在羟基磷灰石暴露方面表征良好的互联的支架，如下进行了几种评估：形态，机械性能，润湿性，钙离子释放和细胞反应评估。将这些评估的结果与通过精密挤压沉积（PED）设备制造的控制支架的结果进行了比较。控制Ped支架具有互连的孔，含有非缺乏羟基磷灰石。因此，通过使用粉末暴露的羟基磷灰石颗粒和制造工艺产生的支架表面的亲水性和表面粗糙度增加了所提出的Wnm支架的细胞连接。此外，由于羟基磷灰石颗粒的暴露可能增强细胞粘附和钙离子释放，因此增加了细胞增殖和分化。还2016 Wiley期刊，INC.J生物保解率B部分：苹果生物摩特，105B：2315-2325,2017。

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