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Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth.

机译:使用非人类的灵长类动物模型研究与感染相关的早产的机制。

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摘要

Preterm birth is the most important direct cause of neonatal mortality and remains a major challenge for obstetrics and global health. Intrauterine infection causes approximately 50% of early preterm births. Animal models using pregnant mice, rabbits or sheep demonstrate the key link between infection and premature birth, but differ in the mechanisms of parturition and placental structure from humans. The nonhuman primate (NHP) is a powerful model which emulates many features of human placentation and parturition. The contributions of the NHP model to preterm birth research are reviewed, emphasising the role of infections and the potential development of preventative and therapeutic strategies.
机译:早产是新生儿死亡率的最重要直接原因,并且仍然是产科和全球健康的主要挑战。宫内感染引起大约50%的早产。使用怀孕小鼠,兔子或绵羊的动物模型证明了感染与早产之间的关键联系,但与人的分娩和胎盘结构机制不同。非人类灵长类动物(NHP)是一个功能强大的模型,可模仿人类胎盘早孕和分娩的许多特征。回顾了NHP模型对早产研究的贡献,强调了感染的作用以及预防和治疗策略的潜在发展。

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