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首页> 外文期刊>Expert review of hematology >The gastrointestinal tract: properties and role in allogeneic hematopoietic stem cell transplantation
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The gastrointestinal tract: properties and role in allogeneic hematopoietic stem cell transplantation

机译：胃肠道：同种异体造血干细胞移植中的性质和作用

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Introduction: The GI-tract is a major target for both the intensive chemo and/or radiotherapy conditioning as well as for GVHD and therefore is closely associated with transplant outcome. Apart from being a target, the GI-tract is also a mediator and therefore is also a key player of the pathogenetic process following allogeneic transplantation.Areas covered: The intestinal homeostasis is regulated through complicated interactions between the key players of this process which are the intestinal epithelium, the intestinal immune system, and the intestinal microbiota. A brief description of these elements, based on published english-language articles in PubMed, as well as their role during the process of allo-HSCT is discussed in this review.Expert commentary: Data on GI-tract properties suggest a central role for the intestine in regulation of immunity, both in healthy - steady state conditions and in pathological states such as during allo-HSCT. Given the fact that in the allogeneic transplant setting severe complications such as infections and GVHD are limiting this treatment modality, understanding the mechanisms that mediate intestinal homeostasis could lead to new preventive methods and improved outcomes.
机译：简介：GI-TRACT是强化化疗和/或放射治疗条件以及GVHD的主要目标，因此与移植结果密切相关。除了目标外，GI-arract也是一个调解蛋白，因此也是同种异体移植后致病过程的关键球员。覆盖：肠道稳态受到这个过程的关键球员之间的复杂相互作用。肠上皮，肠免疫系统和肠道微生物群。在此评论中讨论了基于PubMed的发表的英语语言文章的这些要素的简要描述，以及在此评论中讨论了allo-hsct过程中的作用.Expert评论：关于Gi-Tract属性的数据表明了一个核心作用肠道在治疗免疫调节，无论是健康稳态的状态和病理状态，如Allo-HSCT期间。鉴于同种异体移植制定严重的并发症如感染和GVHD是限制了这种治疗方式，了解肠道稳态可能导致新的预防方法和改进结果的机制。

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