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首页> 外文期刊>Experimental and therapeutic medicine >Effect of transoral endoscopic adenoidectomy on peripheral blood T-lymphocyte subsets in children with obstructive sleep apnea-hypopnea syndrome and its treatment strategy
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Effect of transoral endoscopic adenoidectomy on peripheral blood T-lymphocyte subsets in children with obstructive sleep apnea-hypopnea syndrome and its treatment strategy

机译：传递内镜腺样体切除术对阻塞性睡眠呼吸暂停综合征及其治疗策略的儿童外周血T淋巴细胞亚群的影响及其治疗策略

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摘要

The objective of the present study was to investigate the effect of transoral endoscopic adenoidectomy on peripheral blood T lymphocyte subsets in pediatric patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its treatment strategy. Ninety-eight pediatric patients with adenoidal hypertrophy associated with OSAHS admitted to the Department of Otolaryngology, Xuzhou Children's Hospital were selected. After admission, patients received perfected 24 h polysomnogram monitoring, routine blood examination, fasting blood biochemistry examination, T-lymphocyte subset count, 24 h ambulatory blood pressure monitoring, and nasopharyngeal computed tomography. After patients were diagnosed with adenoidal hypertrophy associated with OSAHS, they underwent transoral endoscopic adenoidectomy with a power microdebrider. Patients were evaluated at 3-, 6-and 12-week follow-up visits. The CD3(+), CD4(+), and CD8(+) T-cell counts, CD4(+)/CD8(+) T lymphocyte ratio, and changes of 24 h ambulatory blood pressure before and after surgery were recorded. After the 6-week follow-up visit, the mean CD4(+) T lymphocyte count in patients was increased significantly compared with that before surgery, the CD4(+)/CD8(+) T lymphocyte ratio increased gradually, and the differences were statistically significant (P < 0.05). The frequency of nocturnal awakening of patients was decreased significantly after surgery and the duration of nocturnal sleep was extended significantly (P < 0.05). Through analysis of the preoperative and postoperative clinical data of pediatric patients, the CD4(+)/CD8(+) T lymphocyte ratio was negatively correlated with mean arterial pressure (MAP) (r=-1.06, P=0.003). In conclusion, adenoidectomy can significantly decrease the MAP in pediatric patients with OSAHS and CD4(+)/CD8(+) T lymphocyte ratio in pediatric patients was significantly negatively correlated with MAP.
机译：本研究的目的是探讨多发性内镜腺体切除术对梗阻性睡眠呼吸暂停综合征（OSAHS）及其治疗策略的儿科患者外周血T淋巴细胞亚群的影响及其治疗策略。徐州儿童医院有98例与奥沙漠患者有关的奥沙漠肥大有关的腺体肥大患者。入院后，接受完善的患者24小时多面动力学监测，常规血液检查，禁食血液生化检查，T淋巴细胞子集合，24小时动态血压监测，鼻咽计算断层扫描。患者被诊断出患有与OSAHs相关的腺样肥大后，它们用电力微小模具接受了多移内窥镜腺样体切除术。患者在3-,6和12周的后续访问中进行评估。 CD3（+），CD4（+）和CD8（+）T细胞计数，CD4（+）/ CD8（+）T淋巴细胞比，并记录了手术前后24小时的动态血压。在6周后访问后，患者的平均CD4（+）T淋巴细胞计数与手术前的患者显着增加，CD4（+）/ CD8（+）T淋巴细胞比逐渐增加，差异是统计学意义（P <0.05）。手术后患者夜间觉醒的频率显着下降，夜间睡眠持续时间显着延长（P <0.05）。通过分析小儿患者的术前和术后临床数据，CD4（+）/ CD8（+）T淋巴细胞比与平均动脉压（MAP）呈负相关（R = -1.06，P = 0.003）。总之，腺体切除术可以显着降低奥沙斯的小儿患者的地图，CD4（+）/ CD8（+）T淋巴细胞比在儿科患者中的比例与地图显着呈负相关。

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