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首页> 外文期刊>Experimental and therapeutic medicine >Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model
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Efficacy and safety of percutaneous microwave coagulation therapy followed by I-125 seed brachytherapy for VX2 hepatic tumors in a rabbit model

机译：经皮微波凝固治疗的功效和安全性，其次在兔模型中的Vx2肝肿瘤的I-125种子近距离放射治疗

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The aim of this study was to evaluate the efficacy and safety of percutaneous microwave coagulation therapy (PMCT) followed by I-125 seed brachytherapy for VX2 liver cancer in rabbits. Eighty New Zealand rabbits were injected with suspensions of VX2 tumor cells to create an animal model. The rabbits were randomly divided into 4 groups (n=20); the control, PMCT, I-125 seed brachytherapy and combination groups. Group A was treated with PMCT at 40 W for 120 sec, group B was treated with I-125 seed brachytherapy and group C was treated with PMCT followed by I-125 seed brachytherapy. Group D were not treated and served as the control group. At 21 days after treatment, the rabbits were sacrificed for pathological assessment. The complete tumor necrosis rate was 19 out of 20 tumors (95%) in group C, 6 (30%) in group A, 0 (0%) in group B and 0 (0%) in the control group. The complete tumor necrosis rate was observed to be significantly different between groups C and A, and between groups C and B (P0.01). No intraheptic metastasis occurred in group C, compared with an incidence of 7 (35%) in group A, 2(10%) in group B and 20 (100%) in the control group. Between groups C and A, and between groups C and D, the intraheptic metastasis rate was statistically significant (P0.01). PMCT followed by I-125 seed brachytherapy increased the rate of carcinoma necrosis and decreased carcinoma metastasis in the VX2 rabbit model. This combined treatment is a safe, effective and minimally invasive therapeutic option for liver cancer.
机译：本研究的目的是评估经皮微波凝固治疗（PMCT）的疗效和安全性，然后是兔VX2肝癌的I-125种子近距离放射治疗。八十次新西兰兔子注射了VX2肿瘤细胞的悬浮液以产生动物模型。将兔子随机分为4组（n = 20）;对照，PMCT，I-125种子近距离放射治疗和组合组。将A组用PMCT处理40倍，持续120秒，B组被I-125种子近距离放射治疗治疗，并用PMCT处理C组，其次是I-125种子近距离放射治疗。 D组未治疗并作为对照组。治疗后21天，为病理评估处死兔子。 C组，第C组，6（0％）的C组，6（30％）中的全部肿瘤坏死率为19族，对照组中的0（0％）。观察到完整的肿瘤坏死率在C组和A之间以及基团C和B之间具有显着差异（P <0.01）。 C组中没有发生钝化转移，与对照组的B组和20（10％）的A，2（10％）中的发病率为7（35％）。在C和A之间，在C和D组之间，诱导术转移率在统计学上显着（P <0.01）。 PMCT之后是I-125种子近距离放射治疗增加了癌坏死的速率和VX2兔模型中的癌转移率降低。这种组合治疗是肝癌的安全，有效和微创的治疗选择。

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