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首页> 外文期刊>Experimental and therapeutic medicine >Effects of different triglyceride-lowering therapies in patients with hypertriglyceridemia-induced acute pancreatitis
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Effects of different triglyceride-lowering therapies in patients with hypertriglyceridemia-induced acute pancreatitis

机译：降甘油酯降低疗法在高甘油三酯血症诱导的急性胰腺炎患者中的影响

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摘要

The aim of the present study was to investigate the effects of various triglyceride (TG)-lowering therapies on hypertriglyceridemia-induced acute pancreatitis (HTGAP). A total of 132 patients with HTGAP were retrospectively divided into an insulin intensive therapy (IIT), a plasma exchange (PE) and a non-intensive insulin therapy (NIIT) group according to the TG-lowering therapies they had received. The clinical and biochemical data of the subjects were analyzed. The baseline data, including sex, age, TG, amylase, severe acute pancreatitis and systemic inflammatory response syndrome were not significantly different among the three groups (P>0.05). The 24-h TG clearance rate (chi(2)=7.74, P=0.021), onset to treatment time (chi(2)=14.50, P 0.05). The incidence of therapy-associated complications in the PE group (30.23%) was higher than that in the IIT (2.17%) and NIIT (4.65%) groups. The difference in the incidence of therapy-associated complications was significant among the three groups (P 0.05). In the PE group, the length of stay was increased compared with that in the IIT and NIIT groups (chi(2)=7.05, P 0.05). The present study suggested that NIIT at presentation had a similar therapeutic efficacy to that of IIT to improve the prognosis of HTGAP, and NIIT and IIT were associated with fewer complications than PE treatment. NIIT may favorably perform in patients presenting early after symptom onset and may be considered for clinical application.
机译：本研究的目的是探讨各种甘油三酯（TG）对高甘油三酯血症诱导的急性胰腺炎（HTGAP）的影响。根据他们收到的TG降低疗法回顾性，总共132名HTGGAP患者，胰岛素强化治疗（IIT），血浆交换（PE）和非密集胰岛素治疗（NIIT）组。分析了受试者的临床和生化数据。基线数据，包括性别，年龄，TG，淀粉酶，严重急性胰腺炎和全身炎症反应综合征在三组中没有显着差异（P> 0.05）。 24-H TG间隙率（CHI（2）= 7.74，P = 0.021），开始治疗时间（CHI（2）= 14.50，p 0.05）。 PE组治疗相关并发症的发病率（30.23％）高于IIT（2.17％）和NIIT（4.65％）组。治疗相关并发症发生率的差异在三组中具有重要意义（p 0.05）。在体育群中，与IIT和NIIT组中的停留程度增加（CHI（2）= 7.05，05）。本研究表明，介绍的NIIT对IIT提高HTGAP预后具有类似的治疗效果，并且NIIT和IIT与比PE治疗更少的并发症相关。 NIIT可能有利地在症状发作早期提前的患者中进行，并且可以考虑临床应用。

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  • 作者

    Yu Shanshan; Yao Dongqi; Liang Xianquan; Jin Kui; Fu Yangyang; Liu Danyu; Zhang Lili; Yang Jing; Song Xiao; Xu Jun; Yu Xuezhong;

  • 作者单位

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Hebei Med Univ Dept Emergency Hosp 2 Shijiazhuang 050000 Hebei Peoples R China;

    Second Peoples Hosp Guiyang Dept Emergency Guiyang 550023 Guizhou Peoples R China;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Emergency 1 Shuaifuyuan Beijing 100730;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 治疗学;
  • 关键词

    hypertriglyceridemia-induced acute pancreatitis; insulin; plasma exchange; prognosis;

    机译：高甘油脂血症诱导的急性胰腺炎;胰岛素;血浆交换;预后;

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