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首页> 外文期刊>Experimental and therapeutic medicine >Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis
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Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis

机译：CT引导的经皮肺肛边和结核瘤灌注化疗治疗胸膜结核病的安全性和有效性

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摘要

The aim of the study was to compare the mid-and long-term effects of different treatments such as CT-guided percutaneous pulmonary paracentesis, tuberculoma perfusing chemotherapy and whole-body standard chemotherapy or extended chemotherapy on safety and effectiveness for pleural chemotherapy. A total of 60 subjects diagnosed to have pleural tuberculosis between February 2010 and February 2014 were prospectively selected for this study and were considered as the experimental group. Seventy pleural tuberculosis patients who underwent treatment between February 2006 and February 2010 were considered as the control group. The patients in the experimental group were treated with CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy of not more than three courses with each course consisting of administration of 0.1 g isoniazid, n 0.5 gkanamyci, 0.2 g levofloxacin, and 1 ml lidocaine once a week for four times. The patients in the control group were treated with whole-body standard or extended chemotherapy regimen 3 similar to 6HRZE(S)/6 similar to 12HR. The patients were followed up for 18 months and the treatment effects were compared. The diameter of tuberculoma in patients of the experimental group during 6, 12 and 18 months was shorter than that of the control group (P<0.05). The total effective rate of treatment and the duration of treatment in experimental group during 18 months were higher than that of control group (P<0.05). The frequency of drug-related complications were lower in comparison with the control group (P<0.05). No surgically acquired complications were observed in the experimental group. Thus, treatments such as CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for pleural tuberculosis are safe and effective, which has greater value and can be promoted for use in the clinical setting.
机译：该研究的目的是比较不同治疗的中期和长期影响，例如CT引导的经皮肺腹腔腹腔腹腔，结核瘤灌注化疗和全身标准化疗或延长化疗对胸膜化疗的安全性和有效性。诊断为2010年2月至2014年2月之间诊断患有胸膜结核病的60名受试者对本研究进行了预先选择，并被视为实验组。七十个胸膜结核病患者在2006年2月和2010年2月之间接受治疗的患者被视为对照组。实验组患者用CT引导的经皮肺腹腔探伤和结核瘤灌注化疗，每种课程由施用0.1g异烟肼，N 0.5 GKANAMYCI，0.2g Levofloxacin，1ml Liatocaine组成的每个课程一周四次。对照组中的患者用全身标准或延长化疗方案3治疗，类似于6hrze（S）/ 6类似于12小时。患者随访18个月，比较治疗效果。在6,12和18个月的实验组患者中结核瘤的直径短于对照组（P <0.05）。在18个月内，实验组治疗的总处理率和治疗持续时间高于对照组（P <0.05）。与对照组相比，药物相关并发症的频率较低（P <0.05）。在实验组中没有观察到手术获得的并发症。因此，诸如CT引导的经皮肺腹腔探伤和肺结核化学疗法的治疗方法是安全且有效的，其具有更大的值，并且可以促进用于临床环境。

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