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Studies of Mitochondrial Sequences in the Nuclear Genome of Animals

机译:动物核基因组中线粒体序列的研究

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摘要

Mitochondrial sequences in the nuclear genome were found in all eukaryotes studied. This review summarizes the data on the history of studying the DNA transfer from mitochondria to nucleus. The mitochondrial sequences located in the nucleus can be used for phylogenetic reconstructions. The practice of identifying insects on the species level using DNA barcoding made it possible to prevent contamination with the homologous sequences of the nuclear origin. These methods eliminate the risk of distortingthe results of phylogenetic studies based on a comparison of nucleotide sequences of mitochondrial genes. The relationships between the aging of mammals and hereditary diseases of humans with insertions of mitochondrial sequences in somatic cells were revealed. The possibility of the inductive transfer of mitochondrial sequences to the nucleus under the influence of viral infections and in the course of aging is considered.
机译:在所有研究的真核生物中都发现了核基因组中的线粒体序列。这篇综述总结了研究DNA从线粒体到细胞核转移的历史数据。位于细胞核中的线粒体序列可用于系统发育重建。使用DNA条形码在物种水平上鉴定昆虫的做法使得防止核起源的同源序列受到污染成为可能。这些方法基于线粒体基因核苷酸序列的比较,消除了扭曲系统发育研究结果的风险。揭示了哺乳动物的衰老与人类遗传性疾病与体细胞中线粒体序列插入之间的关系。考虑了在病毒感染和衰老过程中线粒体序列诱导转移至细胞核的可能性。

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