Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury

Kadekawa Katsumi; Yoshizawa Tsuyoshi; Wada Naoki; Shimizu Takahiro; Majima Tsuyoshi; Tyagi Pradeep; de Groat William C.; Sugaya Kimio; Yoshimura Naoki

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Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury

机译：基于脂质体的局部抑制神经生长因子在膀胱肿瘤大鼠膀胱疼痛期间神经生长因子对膀胱肿瘤性裂缝的影响

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Purpose: To examine (1) whether spinal cord injury (SCI) time-dependently increases the severity of autonomic dysreflexia (AD) and expression levels of bladder nerve growth factor (NGF) protein, and (2) whether local suppression of NGF in the bladder improves SCI-induced AD in rats.

机译：目的：检查（1）脊髓损伤（SCI）是否时间依赖地增加了自主厌重（AD）和膀胱神经生长因子（NGF）蛋白的表达水平的严重程度，以及（2）是否局部抑制NGF 膀胱改善了大鼠的SCI诱导的广告。

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来源
《Experimental Neurology》 |2017年第2017期|共7页
作者
Kadekawa Katsumi; Yoshizawa Tsuyoshi; Wada Naoki; Shimizu Takahiro; Majima Tsuyoshi; Tyagi Pradeep; de Groat William C.; Sugaya Kimio; Yoshimura Naoki;
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作者单位

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

Univ Pittsburgh Sch Med Dept Pharmacol &

Cell Biol Pittsburgh PA USA;

Southern Knights Lab Okinawa Japan;

Univ Pittsburgh Sch Med Dept Urol Suite 700 Kaufmann Med Bldg 3471 Fifth Ave Pittsburgh PA;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
Autonomic dysreflexia; Spinal cord injury; Liposome NGF antisense; Rat;

机译：自主失败;脊髓损伤;脂质体NGF反义;老鼠;

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专利

1. Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury [J] . Kadekawa Katsumi, Yoshizawa Tsuyoshi, Wada Naoki, Experimental Neurology . 2017,第期

机译：基于脂质体的局部抑制神经生长因子在膀胱肿瘤大鼠膀胱疼痛期间神经生长因子对膀胱肿瘤性裂缝的影响
2. Mechanisms inducing autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury [J] . Yoshizawa T., Kadekawa K., Tyagi P., Spinal cord: the official journal of the International Medical Society of Paraplegia . 2015,第3期

机译：脊髓损伤大鼠尿膀胱间距期间诱导自主重症的机制
3. Effects of intravesical onabotulinumtoxinA on bladder dysfunction and autonomic dysreflexia after spinal cord injury: Role of nerve growth factor [J] . ElkeliniM.S., BagliD.J., FehlingsM., BJU international . 2012,第3期

机译：膀胱内肉毒杆菌毒素A对脊髓损伤后膀胱功能障碍和自主神经反射不良的影响：神经生长因子的作用
4. Relationship between tissue composition and biomechanics of the urinary bladder: effects of spinal cord injury on bladder tissue [C] . Nagatomi, J., Getzenberg, . 2004

机译：组织成分与膀胱生物力学之间的关系：脊髓损伤对膀胱组织的影响
5. Plasticity in the rat spinal cord following spinal cord transection: Contribution to autonomic dysreflexia. [D] . Krenz, Natalie Rae. 1999

机译：脊髓横断后大鼠脊髓的可塑性：导致自主神经反射不良。
6. Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury [O] . Katsumi Kadekawa, Tsuyoshi Yoshizawa, Naoki Wada, -1

机译：基于脂质体的膀胱神经生长因子局部抑制对脊髓损伤大鼠膀胱扩张时自主神经反射异常的影响
7. Severe, Protracted Spasm of Urinary Bladder and Autonomic Dysreflexia Caused by Changing the Suprapubic Catheter in a Cervical Spinal Cord Injury Patient: Treatment by a Bolus Dose and Increased Total Daily Dose of Intrathecal Baclofen [O] . Subramanian Vaidyanathan, Tun Oo, Bakul M. Soni, 2016

机译：通过在颈脊髓损伤患者中改变肠道导管的严重，延长的膀胱痉挛和自主重症引起的：通过推注剂量治疗，增加了鞘内成杆菌的总剂量
8. Anti-NGF Local Therapy for Autonomic Dysreflexia in Spinal Cord Injury. [R] . Yoshimura, N. 2014

机译：抗NGF局部治疗脊髓损伤的自主神经反射不良。

Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury

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