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首页> 外文期刊>Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association >Evaluation of Vascular Remodeling in Carotid Atherosclerosis Among Type 2 Diabetes Mellitus Patients Using High-Frequency Ultrasonography Combined with Serum Resistin
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Evaluation of Vascular Remodeling in Carotid Atherosclerosis Among Type 2 Diabetes Mellitus Patients Using High-Frequency Ultrasonography Combined with Serum Resistin

机译：使用高频超声检查血清抑制患者2型糖尿病患者颈动脉粥样硬化中血管改造的评价

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摘要

Diabetes remains a long standing public health issue among the Chinese population, with an incidence of up to 11.6%, of which type 2 diabetes mellitus (T2DM) accounts for 85%-95%. During this study, we aimed to elucidate the value of high-frequency ultrasonography (HFUS) combined with serum resistin on vascular remodeling (VR) in carotid atherosclerosis (CA) among patients suffering from T2DM. A total of 432 T2DM were recruited and assigned into the short T2DM duration group (5 years), middle T2DM duration group (5 similar to 10 years) and long T2DM duration group (10 years), while another 172 healthy cases were recruited as the control group. The intima-media thickness (IMT) as well as plaque score, detection rate and type were detected by the HFUS. The respective blood pressure readings were measured and pulse pressure was calculated accordingly. The serum resistin level, remodeling incidence and type, levels of total cholesterol (TC), fasting blood glucose (FBG), low-density lipoprotein cholesterol (LDL-C), high-density liproprotein cholesterol (HDL-C), and triglyceride (TG) were measured. The correlation between IMT, the plaque detection rate and blood pressure were analyzed. A receiver operating characteristic (ROC) curve was constructed in order to evaluate the impact of VR in CA on T2DM patients who were solely using HFUS and serum resistin respectively, as well as a combination of HFUS with serum resistin. As In comparison with the control group, the short, middle and long T2DM duration groups all displayed increased IMT, plaque score and detection rate, serum resistin level and VR incidence, especially for the long T2DM duration group. Levels of TC, TG, FBG and LDL-C were much higher while HDL-C was lower among patients with T2DM than those in the control group. A positive correlation was detected between the disease course and IMT. The detection rate of plaque with thickening IMT exhibited upregulated levels when compared to those with normal IMT. The HFUS, serum resistin and HFUS combined with serum resistin respective areas under the ROC curve were 0.873, 0.867 and 0.923, respectively, suggesting that the combination of HFUS and serum resistin was superior to that of individual HFUS or individual serum resistin in regard to the impact of VR in CA on T2DM patients. The results of this study revealed that the combination of HFUS and serum resistin was superior to individual HFUS or individual serum resistin in relation to its ability to evaluate the impact of VR in CA in patients with T2DM.
机译：糖尿病仍然是中国人口中长期存在的公共卫生问题，发病率高达11.6％，其中2型糖尿病（T2DM）占85％-95％。在本研究期间，我们旨在阐明高频超声（HFU）与血清抑制（VR）在颈动脉粥样硬化（CA）中的血清抑制（VR）的价值阐明，患有T2DM的患者。招募了432个T2DM并分配到短的T2DM持续时间组（＆; 5年），中间T2DM持续时间组（5岁以下）和长T2DM持续时间组（＆ 10年），而另外172例健康病例被招募作为对照组。 HFU检测到内部介质厚度（IMT）以及斑块分数，检测率和类型。测量各自的血压读数，相应地计算脉冲压力。血清抵抗素水平，重塑发病率和类型，总胆固醇的水平（Tc），空腹血糖（FBG），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C）和甘油三酯（测量TG）。分析了IMT，斑块检测率和血压之间的相关性。构建了一种接收器操作特征（ROC）曲线，以评估VR在CA上的影响，分别使用HFU和血清抗性的T2DM患者以及HFU与血清抗性的组合。与对照组相比，短，中和长的T2DM持续时间基团全部显示IMT，斑块评分和检测率，血清抵抗素水平和VR发病率，特别是对于长T2DM持续时间组。 TC，TG，FBG和LDL-C的水平要高得多，而T2DM的HDL-C低于对照组的患者。在疾病过程和IMT之间检测到阳性相关性。与具有正常IMT的那些相比，斑块具有增厚IMT的斑块的检出速率表现出上调水平。中ROC曲线下的血清抗血清抗性的HFU，血清含量和HFU分别为0.873,0.867和0.923，表明HFU和血清抗性的组合优于单个HFU或单个血清抵抗型VR在CA对T2DM患者的影响。该研究的结果表明，HFU和血清抗性的组合优于各个HFU或单个血清抵抗蛋白，其有关其在T2DM患者中评估VR在CA中的影响。

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