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首页> 外文期刊>Expert opinion on pharmacotherapy >Existing antimalarial agents and malaria-treatment strategies.
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Existing antimalarial agents and malaria-treatment strategies.

机译：现有的抗疟剂和疟疾治疗策略。

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摘要

In the absence of prompt and efficacious treatment, malaria patients may progress within a few hours from having minor symptoms to severe disease and death. These last years have seen the development of several artemisinin-based combinations, new treatments for severe malaria patients, and new strategies such as intermittent preventive treatment or the home-based/near-home management of malaria. The health sector is now confronted with several treatment options and strategies, in contrast with the period when chloroquine monotherapy was the standard treatment. The major challenge remains the large-scale deployment, in the most efficient way, of the tools available today, including artemisinin-based combination treatments, within health systems that remain extremely weak in malaria endemic countries, particularly in sub-Saharan Africa. Health system research, exploring new potential approaches for the large-scale implementation of these interventions, should be promoted in parallel with that on new therapeutic agents to be used in the unlucky event of the emergence and spread of artemisinin resistance. The prospects of substantially decreasing the malaria burden are brighter today than 20 - 30 years ago, but the efforts and resources committed to this purpose should be maintained over a long period.
机译：在没有迅速和有效的治疗的情况下，疟疾患者可能在几小时内进行较小的症状对严重的疾病和死亡。这些过去几年已经看到了几种基于青蒿素的组合的发展，对严重疟疾患者的新治疗，以及间歇预防性治疗或疟疾的家庭/近家庭管理等新策略。卫生部门现在遇到了几种治疗方案和策略，与氯喹啉疗法是标准治疗的时期相比。主要挑战仍然是大规模的部署，以最有效的方式在今天提供的工具，包括基于青蒿素的组合治疗，在疟疾流行国家仍然非常弱的卫生系统中，特别是在撒哈拉以南非洲。卫生系统研究，探索这些干预措施的大规模实施的新潜在方法，应与新的治疗剂上的新的治疗剂一起促进，以便在武术素抵抗的出现和传播的不幸事件中使用。大大减少疟疾负担的前景在于今天比20 - 30年前更加明亮，但致力于此目的的努力和资源应保持长时间。

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  • 来源
    《Expert opinion on pharmacotherapy》 |2009年第8期|共16页
  • 作者

    DAlessandro U;

  • 作者单位

    Department of Parasitology Institute of Tropical Medicine Nationalestraat 10 B-2000 Antwerp Belgium.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
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