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Sex-related differences in the wheel-running activity of mice decline with increasing age

机译：随着年龄的增加，小鼠车轮运行活动的性与差异

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摘要

Laboratory mice of both sexes having free access to running wheels are commonly used to study mechanisms underlying the beneficial effects of physical exercise on health and aging in human. However, comparative wheel-running activity profiles of male and female mice for a long period of time in which increasing age plays an additional role are unknown. Therefore, we permanently recorded the wheel-running activity (i.e., total distance, median velocity, time of breaks) of female and male mice until 9 months of age. Our records indicated higher wheel-running distances for females than males which were highest in 2-month-old mice. This was mainly reached by higher running velocities of the females and not by longer running times. However, the sex-related differences declined in parallel to the age-associated reduction in wheel-running activities. Female mice also showed more variances between the weekly running distances than males, which were recorded most often for females being 4-6 months old but not older. Additional records of 24-month-old mice of both sexes indicated highly reduced wheel-running activities at old age. Surprisingly, this reduction at old age resulted mainly from lower running velocities and not from shorter running times. Old mice also differed in their course of night activity which peaked later compared to younger mice. In summary, we demonstrated the influence of sex on the age-dependent activity profile of mice which is somewhat contrasting to humans, and this has to be considered when transferring exercise-mediated mechanism from mouse to human. (C) 2016 Published by Elsevier Inc.
机译：自由进入跑轮的两性的实验室小鼠通常用于研究潜在的体育锻炼对人类健康和衰老的有益影响的机制。然而，长时间的男性和女性老鼠的比较轮运行活性概况在其中增加年龄扮演额外的作用是未知的。因此，我们永久记录了女性和雄性小鼠的车轮运行的活动（即总距离，中位数，休息时间），直到9个月的年龄。我们的记录表示，女性的距离高于2个月大的小鼠中最高的男性的距离。这主要是由女性的较高运行速度达到而不是较长的运行时间达成。然而，与轮跑活动的年龄相关的减少有关的性别差异差异。女性小鼠在每周运行的距离之间也比男性更常见的差异，这些距离最常用于女性为4-6个月，但并不老。两性24个月大小的额外记录表明老年人的高度减少的车辆活动。令人惊讶的是，这种旧时期的减少主要来自较低的运行速度，而不是从较短的运行时间。老鼠在他们的夜间活动过程中也有所不同，后来与年轻小鼠相比达到尖峰。总之，我们证明了性别对与人类造成鲜明对比的小鼠的年龄依赖性活性概况的影响，并且在将运动介导的机制转移到人类时，必须考虑这一点。 （c）2016年由elsevier公司发布

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  • 来源
    《Experimental Gerontology》 |2017年第2期|共9页
  • 作者

    Bartling Babett; Al-Robaiy Samiya; Lehnich Holger; Binder Leonore; Hiebl Bernhard; Simm Andreas;

  • 作者单位

    Univ Hosp Halle Saale Middle German Heart Ctr Dept Cardiac Surg Halle Saale Germany;

    Univ Hosp Halle Saale Middle German Heart Ctr Dept Cardiac Surg Halle Saale Germany;

    Martin Luther Univ Halle Wittenberg Fac Med Ctr Med Basic Res Halle Saale Germany;

    Univ Hosp Halle Saale Middle German Heart Ctr Dept Cardiac Surg Halle Saale Germany;

    Martin Luther Univ Halle Wittenberg Fac Med Ctr Med Basic Res Halle Saale Germany;

    Univ Hosp Halle Saale Middle German Heart Ctr Dept Cardiac Surg Halle Saale Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 老年病学;
  • 关键词

    Age; Activity; Sex Mouse; Wheel running;

    机译：年龄;活动;性别鼠标;车轮跑步;

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