TRAP1: a viable therapeutic target for future cancer treatments?

Lettini Giacomo; Maddalena Francesca; Sisinni Lorenza; Condelli Valentina; Matassa Danilo Swann; Costi Maria Paola; Simoni Daniele; Esposito Franca; Landriscina Matteo

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TRAP1: a viable therapeutic target for future cancer treatments?

机译：Trap1：未来癌症治疗的可行治疗目标？

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Introduction: HSP90 molecular chaperones (i.e., HSP90a, HSP90 beta, GRP94 and TRAP1) are potential therapeutic targets to design novel anticancer agents. However, despite numerous designed HSP90 inhibitors, most of them have failed due to unfavorable toxicity profiles and lack of specificity toward different HSP90 paralogs. Indeed, a major limitation in this field is the high structural homology between different HSP90 chaperones, which significantly limits our capacity to design paralog-specific inhibitors.

机译：简介：HSP90分子伴侣（即，HSP90A，HSP90 Beta，GRP94和Trap1）是设计新型抗癌剂的潜在治疗目标。然而，尽管有许多设计的HSP90抑制剂，但由于对不同HSP90副葡萄球的毒性谱和缺乏特异性，它们中的大多数都失败。实际上，该领域的一个主要限制是不同HSP90伴侣之间的高结构同源性，这显着限制了我们设计副古曲甙特异性抑制剂的能力。

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来源
《Expert opinion on therapeutic targets》 |2017年第12期|共11页
作者
Lettini Giacomo; Maddalena Francesca; Sisinni Lorenza; Condelli Valentina; Matassa Danilo Swann; Costi Maria Paola; Simoni Daniele; Esposito Franca; Landriscina Matteo;
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作者单位

IRCCS Referral Canc Ctr Basilicata Lab Preclin &

Translat Res Rionero In Vulture Italy;

IRCCS Referral Canc Ctr Basilicata Lab Preclin &

Translat Res Rionero In Vulture Italy;

IRCCS Referral Canc Ctr Basilicata Lab Preclin &

Translat Res Rionero In Vulture Italy;

IRCCS Referral Canc Ctr Basilicata Lab Preclin &

Translat Res Rionero In Vulture Italy;

Univ Naples Federico II Dept Mol Med &

Med Biotechnol Via Pansini 5 I-80131 Naples Italy;

Univ Modena &

Reggio Emilia Dept Life Sci Modena Italy;

Univ Ferrara Dept Chem &

Pharmaceut Sci Ferrara Italy;

Univ Naples Federico II Dept Mol Med &

Med Biotechnol Via Pansini 5 I-80131 Naples Italy;

IRCCS Referral Canc Ctr Basilicata Lab Preclin &

Translat Res Rionero In Vulture Italy;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Cancer; endoplasmic reticulum; HSP90; mitochondria; molecular chaperone; protein quality control; TRAP1; tumor metabolism;

机译：癌症;内质网;HSP90;线粒体;分子伴侣;蛋白质质量控制;TRAP1;肿瘤新陈代谢;

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专利

1. TRAP1: a viable therapeutic target for future cancer treatments? [J] . Lettini Giacomo, Maddalena Francesca, Sisinni Lorenza, Expert opinion on therapeutic targets . 2017,第7a12期

机译：Trap1：未来癌症治疗的可行治疗目标？
2. TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors [J] . Byoung Heon Kang BMB Reports . 2012,第1期

机译：TRAP1调节癌细胞和线粒体靶向TRAP1抑制剂的线粒体生命或死亡决策
3. Current status and future prospects of transforming growth factor‐β as a potential prognostic and therapeutic target in the treatment of breast cancer [J] . Amerizadeh Forouzan, Bahrami Afsane, Khazaei Majid, Journal of cellular biochemistry. . 2019,第5期

机译：将生长因子-β转化为乳腺癌治疗中的潜在预后和治疗靶标的现状和未来前景
4. Merging Therapeutic and Diagnostic Imaging: Phospholipid Ether-Based Targeting Approaches for Broad Spectrum Cancer Detection and Treatment [C] . Joseph Grudzinski 8th International Conference on Isotopes 2014 . 2014

机译：融合治疗和诊断成像：基于磷脂醚的靶向方法用于广谱癌症的检测和治疗
5. Cadherin-11mediation of tumor progression and invasion in poor prognosis cancers: A viable therapeutic target. [D] . Guidry Auvil, Jaime Marie. 2009

机译：在不良预后的癌症中，Cadherin-11介导的肿瘤进展和侵袭：可行的治疗靶点。
6. Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer [O] . Kai Xiong, Hejun Zhang, Yang Du, 2019

机译：确定HDAC9作为治疗胃癌的可行治疗靶标
7. Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer [O] . Kai Xiong, Hejun Zhang, Yang Du, 2019

机译：HDAC9作为治疗胃癌的可行治疗靶标
8. Activated FGFR2 as a Viable Therapeutic Target in a Subset of Ovarian Cancers [R] . Pollack, P. 2009

机译：激活的FGFR2作为卵巢癌子集中的可行治疗靶标

TRAP1: a viable therapeutic target for future cancer treatments?

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