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首页> 外文期刊>Expert opinion on therapeutic targets >Programmed cell death in human pathogenic fungi - a possible therapeutic target
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Programmed cell death in human pathogenic fungi - a possible therapeutic target

机译：人致病真菌中的编程细胞死亡 - 一种可能的治疗目标

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Introduction: Diseases caused by pathogenic fungi are increasing because of antibiotic overuse, the rise of immunosuppressive therapies, and climate change. The limited variety of antimycotics and the rapid adaptation of pathogenic fungi to antifungal agents serve to exacerbate this issue. Unfortunately, about 1.6 million people are killed by fungal infections annually. Areas covered: The discovery of the small antimicrobial proteins produced by microorganisms, animals, humans, and plants will hopefully overcome challenges in the treatment of fungal infections. These small proteins are highly stable and any resistance to them rarely evolves; therefore, they are potentially good candidates for the treatment and prevention of infections caused by pathogenic fungi. Some of these proteins target the programmed cell death machinery of pathogenic fungi; this is potentially a novel approach in antimycotic therapies. In this review, we highlight the elements of apoptosis in human pathogenic fungi and related model organisms and discuss the possible therapeutic potential of the apoptosis-inducing, small, antifungal proteins. Expert opinion: Small antimicrobial proteins may establish a new class of antimycotics in the future. The rarity of resistance and their synergistic effects with other frequently used antifungal agents may help pave the way for their use in the clinic.
机译：介绍：由于抗生素过度使用，免疫抑制疗法的兴起和气候变化，由致病性真菌引起的疾病增加。有限种类的抗炎和致病真菌对抗真菌剂的快速调整用于加剧该问题。遗憾的是，每年由真菌感染杀死约160万人。所涵盖的区域：发现微生物，动物，人类和植物产生的小抗菌蛋白质的发现将希望克服治疗真菌感染的挑战。这些小蛋白质是高度稳定的，并且对它们的任何抗性很少发展;因此，它们是治疗和预防受病原真菌引起的感染的潜在候选者。其中一些蛋白质靶向致病性真菌的编程细胞死亡机制;这可能是抗霉疗法的新方法。在本综述中，我们突出了人致病真菌和相关模型生物中凋亡的元素，并讨论了凋亡诱导，小型抗真菌蛋白的可能治疗潜力。专家意见：小抗菌蛋白可以在未来建立一类新的抗菌病。耐抗性的罕见性及其与其他经常使用的抗真菌剂的协同效应可能有助于为其在临床中使用的方式铺平。

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