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首页> 外文期刊>Expert opinion on therapeutic targets >Chemokines and antagonists in non-Hodgkin's lymphoma
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Chemokines and antagonists in non-Hodgkin's lymphoma

机译：非霍奇金淋巴瘤中的趋化因子和拮抗剂

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摘要

Background: Chemokines and their receptors are a large family of molecules that control the trafficking of immune cells during their development and in response to inflammation. Non Hodgkin's lymphoma (NHL) derives from the neoplastic transformation of lymphocytes at different stages of differentiation and may show systemic, nodal and extranodal localisation as well as metastasis in different sites. Objective: To investigate the role of the chemokine system in the pathology of NHL and as a potential drug target in this disease. Method: The expression of chemokines and receptors by different NHL subtypes as well as their likely functional role in terms of lymphoma tissue localisation, lymphoma growth, tumour angiogenesis and recruitment of immune cells are reviewed. The data regarding antagonists or chemokines as potential therapeutic agents for NHL is discussed. Results/conclusions: NHL's express functional chemokine receptors, which, at least in part, dictate tissue localisation and perhaps metastatic potential. Different types of chemokine antagonists have been tested in vitro and in vivo and several peptide or small molecule inhibitors have reached Phase I/II clinical trials for different diseases. Although the field is in its early days, interesting compounds are being developed, directed especially against homeostatic chemokine receptors.
机译：背景：趋化因子及其受体是一家大家庭，可在其开发期间控制免疫细胞和炎症。非霍奇金的淋巴瘤（NHL）源于不同分化阶段的淋巴细胞的肿瘤转化，并且可以显示出系统性，节点和外部定位以及不同部位的转移。目的：探讨趋化因子系统在NHL病理学中的作用，也是本病的潜在药物靶标。方法：综述了不同NHL亚型的趋化因子和受体的表达，以及它们在淋巴瘤组织定位，淋巴瘤生长，肿瘤血管生成和免疫细胞募集方面的可能功能作用。讨论了关于拮抗剂或趋化因子作为NHL潜在治疗剂的数据。结果/结论：NHL的表达功能趋化因子受体，至少部分地规定了组织定位和可能的转移潜力。不同类型的趋化因子拮抗剂已经在体外测试，体内测试，几种肽或小分子抑制剂已达到不同疾病的I / II临床试验。虽然该领域处于早期，正在开发有趣的化合物，尤其是对宿命期趋化因子受体的影响。

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