• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on therapeutic targets >Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight
【24h】

Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight

机译：Sertoli细胞是睾丸中环保毒性的靶标的 - 机械和治疗洞察力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Sertoli cells support germ cell development in the testis via an elaborate network of cell junctions that confers structural, communicating, and signaling support. However, Sertoli cell junctions and cytoskeletons are the target of environmental toxicants. Because germ cells rely on Sertoli cells for the provision of structural/functional/nutritional support, exposure of males to toxicants leads to germ cell exfoliation due to Sertoli cell injuries. Interestingly, the molecular mechanism(s) by which toxicants induce cytoskel-etal disruption that leads to germ cell exfoliation is unclear, until recent years, which are discussed herein. This information can possibly be used to thera-peutically manage toxicant-induced infertility/subfertility in human males. Areas covered: In this review, we provide a brief update on the use of Sertoli cell system developed for rodents and humans in vitro, which can be deployed in any research laboratory with minimal upfront setup costs. These systems can be used to collect reliable data applicable to studies in vivo. We also discuss the latest findings on the mechanisms by which toxicants induce Sertoli cell injury, in particular cytoskeletal disruption. We also identify candidate molecules that are likely targets of toxicants.Expert opinion: We provide two hypothetical models delineating the mechanism by which toxicants induce germ cell exfoliation and blood-testis barrier disruption. We also discuss molecules that are the targets of toxicants as therapeutic candidates.
机译：简介：塞托利细胞通过赋予结构，通信和信令支持的细胞连接网络来支持睾丸中的生殖细胞开发。然而，Sertoli细胞连接和细胞骨架是环境毒物的靶标。由于生物细胞依赖于血清细胞提供结构/功能/营养载体，因此雄性暴露于毒物导致由于塞托细胞损伤引起的胚芽细胞剥离导致生殖细胞剥离。有趣的是，毒物的分子机制诱导细胞泡型 - Eval破坏，导致生殖细胞去角质尚不清楚，直到近年来，本文讨论。该信息可能用于治疗人类雄性的毒性诱导的毒性不孕症/体育症。所涵盖的区域：在本次审查中，我们在体外开发的Sertoli细胞系统的使用简要了解，可以在任何具有最小前期设置成本的任何研究实验室中部署。这些系统可用于收集适用于体内研究的可靠数据。我们还讨论了毒物诱导血清细胞损伤的机制的最新发现，特别是细胞骨骼破坏。我们还识别可能是毒物靶标的候选分子.Pert意见：我们提供了两个假设模型，描绘了毒物诱导生殖细胞剥离和血液睾丸屏障中断的机制。我们还讨论了作为治疗性候选人的毒物靶标的分子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号