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Fatty acid synthase (FASN) as a therapeutic target in breast cancer

机译:脂肪酸合成酶(FASN)作为乳腺癌的治疗靶标

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Introduction: Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a model to explain how FASN is intertwined with various signaling networks to cell-autonomously regulate breast cancer initiation and progression, FASN has received considerable attention as a therapeutic target. However, despite the ever-growing evidence demonstrating the involvement of FASN as part of the cancer-associated metabolic reprogramming, translation of the basic science-discovery aspects of FASN blockade to the clinical arena remains a challenge.
机译:介绍:十年前,我们提出了乳腺癌脂肪酸合成酶(FASN)的代谢致癌性质。 由于该假设的概念,提供了一种模型来解释FASN如何与各种信号网络交织在细胞 - 自主调节乳腺癌启动和进展中,FASN作为治疗目标得到了相当大的关注。 然而,尽管有了不断增长的证据证明FASN作为癌症相关的代谢重编程的一部分的参与,但FASN封锁的基本科学发现方面的翻译仍然是一个挑战。

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