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Targeting ZBP-89 for the treatment of hepatocellular carcinoma

机译：靶向ZBP-89用于治疗肝细胞癌

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Introduction: Zinc-binding protein-89 (ZBP-89) is a Kriippel-type zinc-finger transcription factor that regulates target gene expression profiles via directly binding to GC-rich gene promoters, recruiting chromatin modifiers or by interacting with other proteins. The importance of ZBP-89 in the regulation of cell cycle arrest and apoptosis has led to increased interest and investigations for its role in cancer development. Areas covered: We describe ZBP-89 as a candidate therapeutic target for hepatocellular carcinoma (HCC) from several perspectives. ZBP-89 can upregulate apoptosis in HCC in a p53-dependent or -independent manner. In addition, the negative regulation of ZBP-89 on liver cancer sternness sheds light on its possible effect on sensitizing HCC to chemotherapies and the reduction of HCC relapse. The prognostic significance of ZBP-89 in HCC patients further suggests its clinical importance as a potential tumor suppressor. Expert opinion: Given the roles of ZBP-89 in HCC, we believe, ZBP-89 is a promising therapeutic target for enhancing apoptosis and diminishing the liver cancer sternness. At the same time, we also face a series of challenges, especially in the clinical implication of ZBP-89. Resolving the current controversies will advance the development of ZBP-89 for anti-HCC therapy.
机译：简介：锌结合蛋白-89（ZBP-89）是一种Krippel型锌 - 手指转录因子，通过直接结合GC的基因启动子，募集染色质调节剂或与其他蛋白质相互作用来调节靶基因表达谱。 ZBP-89在细胞周期停滞和细胞凋亡中的重要性导致其在癌症发展中作用的兴趣和调查增加。涵盖的区域：从几种角度来看，我们将ZBP-89描述为肝细胞癌（HCC）的候选治疗靶标。 ZBP-89可以以P53依赖性或依赖性方式在HCC中上调凋亡。此外，ZBP-89对肝癌的负调控似乎在敏感HCC对化疗和HCC复发的减少的影响下，揭示了它可能的影响。 ZBP-89在HCC患者中的预后意义进一步表明其临床重要性作为潜在的肿瘤抑制作用。专家意见：鉴于ZBP-89在HCC中的角色，我们认为，ZBP-89是增强细胞凋亡并减少肝癌严厉的有希望的治疗靶标。与此同时，我们也面临着一系列挑战，特别是在ZBP-89的临床意义中。解决目前的争议将推进ZBP-89的发展抗HCC治疗。

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