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首页> 外文期刊>Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association >Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area
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Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area

机译：胃癌血清标志物评价及胃癌地区的高发病率及死亡率疾病

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BackgroundMongolia has the highest mortality rate of gastric cancer. The early detection of cancer and down-staging screening for high risk patients are essential. Therefore, we aimed to validate serum markers for stratifying patients for further management.MethodsEndoscopy and histological examination were performed to determine high risk and gastric cancer patients. Rapid urease test, culture and histological tests were performed to diagnose Helicobacter pylori infection. Serum pepsinogen (PG) I and II and anti-H. pylori IgG were measured by ELISA. Receiver Operating Characteristic analysis was used to extract the best cut-off point.ResultsTotally 752 non-cancer and 50 consecutive gastric cancer patients were involved. The corpus chronic gastritis (72%: 36/50 vs. 56.4%: 427/752), corpus atrophy (42.0%: 21/50 vs. 18.2%: 137/752) and intestinal metaplasia (IM) (64.0%: 32/50 vs. 21.5%: 162/752) were significantly higher in gastric cancer than non-cancer patients, respectively. Therefore, corpus chronic gastritis, corpus atrophy and IM were considered as high risk disease. The best serum marker to predict the high risk status was PGI/II 3.1 (sensitivity 67.2%, specificity 61%) and PGI/II further reduced to 2.2 (sensitivity 66%, specificity 65.1%) together with PGI 28ng/mL (sensitivity 70%, specificity 70%) were the best prediction for gastric cancer. The best cut-off point to diagnose H. pylori infection was anti-H. pylori IgG 8U/mL. Multivariate analysis showed that anti-H. pylori IgG 8U/mL and PGI/II 3.1 increased risk for high risk status and PGI/II 3.1 remained to increase risk for gastric cancer.ConclusionThe serum diagnosis using PGI/II 3.1 cut-off value is valuable marker to predict high risk patients for population based massive screening.
机译：BackgroundMongolia具有最高的胃癌死亡率。早期检测高危患者的癌症和下分期筛查是必不可少的。因此，我们旨在验证用于分层患者进行进一步管理的血清标记。进行方法检查和组织学检查以确定高风险和胃癌患者。进行快速脲酶测试，培养和组织学试验以诊断幽门螺杆菌感染。血清胃肠原（pg）I和II和抗H。通过ELISA测量幽门螺杆菌IgG。接收器操作特征分析用于提取最佳截止点。涉及752例非癌症和50例连续胃癌患者。语料库慢性胃炎（72％：36/50与56.4％：427/752），语料库萎缩（42.0％：21/50 vs.18.2％：137/752）和肠道成钙（IM）（64.0％：32 / 50与21.5％：162/752）分别比非癌症患者显着高于胃癌。因此，语料树慢性胃炎，语料库萎缩和IM被认为是高风险疾病。为了预测高风险状态的最佳血清标记是PGI / II <3.1（灵敏度67.2％，特异性61％）和PGI / II进一步降低至<2.2（敏感性66％，特异性65.1％）与PGI＆ 28NG / mL（敏感性70％，特异性70％）是对胃癌的最佳预测。诊断H.幽门螺杆菌感染的最佳截止点是抗H. Pylori IgG＆ 8u / ml。多变量分析显示抗H。幽门螺杆菌IgG＆ 8U / ml和PGI / II＆ 3.1高风险状态的风险增加，PGI / II＆ 3.1仍然增加胃癌风险。结论使用PGI / II＆ 3.1截止值的血清诊断有价值的标志物预测基于群体的大量筛选患者。

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