• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association >Polymorphisms in CARS are associated with gastric cancer risk: a two-stage case–control study in the Chinese population
【24h】

Polymorphisms in CARS are associated with gastric cancer risk: a two-stage case–control study in the Chinese population

机译：汽车中的多态性与胃癌风险有关：中国人口中的两阶段病例对照研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background The cysteinyl transfer RNA synthetase gene ( CARS ) is located on chromosome band 11p15.5, which is an important tumor-suppressor gene region. Mutations in CARS have been identified in many kinds of cancers; however, evidence for a relationship between genetic variants in CARS and gastric cancer at the population level is still lacking. Thus, we explored the association of variants in CARS with gastric cancer using a two-stage case–control strategy in Chinese. Methods We undertook a two-stage case–control study to investigate the association between polymorphisms in CARS and risk of gastric cancer with use of an Illumina Infinium ? BeadChip and an ABI 7900 system. Results Four single nucleotide polymorphisms (SNPs) were significantly associated with gastric cancer risk in both the discovery stage and the validation stage after adjustment for age and sex. In addition, the combined results of the two stages showed these SNPs were related to gastric cancer risk ( P false?discovery?rate ?≤?0.001 for rs384,490, rs729662, rs2071101, and rs7394702). In silico analyses revealed that rs384490 and rs7394702 could affect transcription factor response elements or DNA methylation of CARS , and rs729662 was associated with the prognosis of gastric cancer. Additionally, expression quantitative trait loci analysis showed rs384490 and rs729662 might alter expression of CARS -related genes. Conclusions The potential functional SNPs in CARS might influence the biological functions of CARS or CARS -related genes and ultimately modify the occurrence and development of gastric cancer in Chinese. Further large-scale population-based studies or biological functional assays are warranted to validate our findings.
机译：摘要背景Cysteinyl转移RNA合成酶基因（汽车）位于11p15.5的染色体带11p15.5上，这是一个重要的肿瘤抑制基因区域。汽车中的突变已在多种癌症中鉴定出来;但是，仍然缺乏遗传症和胃癌遗传变异之间关系的证据。因此，我们使用两阶段的案例控制策略探索了胃癌的汽车中变种的协会。方法采用两阶段的案例对照研究，探讨汽车多态性与胃癌的危险与利用illumina infinium之间的关联吗？珠片和ABI 7900系统。结果在调整年龄和性别后，4种单一核苷酸多态性（SNP）与胃癌风险显着与胃癌风险有关。此外，两个阶段的组合结果显示这些SNP与胃癌风险有关（P false？发现？率？≤10.001，RS384,490，RS729662，RS2071101和RS7394702）。在硅分析中，揭示了RS384490和RS7394702可能影响汽车的转录因子响应元件或DNA甲基化，RS729662与胃癌的预后有关。另外，表达定量性状基因座分析显示RS384490和RS729662可能会改变汽车相关基因的表达。结论汽车中的潜在功能SNP可能会影响汽车或汽车的生物学功能 - 相关基因，最终改变胃癌的发生和发展。进一步的基于大规模的人群的研究或生物学功能测定值得验证我们的研究结果。

著录项

  • 来源
  • 作者

    Tian Tian; Ling Xiao; Jiangbo Du; Xun Zhu; Yayun Gu; Na Qin; Caiwang Yan; Li Liu; Hongxia Ma; Yue Jiang; Jiaping Chen; Hao Yu; Juncheng Dai;

  • 作者单位

    Department of Epidemiology and Biostatistics School of Public Health Nantong University;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Digestive Endoscopy Center The First Affiliated Hospital of Nanjing Medical University and Jiangsu;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

    Department of Epidemiology and Biostatistics Collaborative Innovation Center for Cancer;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Gastric cancer; Susceptibility; CARS; Polymorphism; Genetic association;

    机译：胃癌;易感性;汽车;多态性;遗传协会;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号