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首页> 外文期刊>Life sciences >IkappaBalpha polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: a case-control study.
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IkappaBalpha polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: a case-control study.

机译：IkappaBalpha多态性与南方华人人群患胃癌的风险增加相关：一项病例对照研究。

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AIM: Nuclear factor-kappa B inhibitor alpha (IkappaBalpha) polymorphisms were found to be associated with inflammatory diseases. However, the association between IkappaBalpha polymorphisms with gastric cancer is still unknown. We aim to investigate the association between IkappaBalpha polymorphisms and gastric cancer risk in a large population-based case-control study among southern Chinese. MAIN METHODS: A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 1010 gastric cancer patients and 1500 healthy controls were enrolled in this study. IkappaBalpha polymorphisms were identified by sequencing of IkappaBalpha gene ranging from the 2kb promoter region to the 3.5kb genomic region. Polymorphisms in IkappaBalpha were analyzed by TaqMan SNP genotyping assay. KEY FINDINGS: rs17103265 deletion homozygote (-/-) had significantly increased gastric cancer risk (OR=2.11, 95% CI=1.17-3.83, P=0.01), compared with rs17103265 T homozygote (TT). rs17103265 (-/-) genotype was significantly associated with increased risk of intestinal-type gastric cancer with (OR=2.21, 95% CI=1.19-4.08, P=0.01), but not with the diffuse or mix type of gastric cancer. rs17103265 (-/-) was associated with poorly differentiated gastric cancer (OR=2.05, 95% CI=1.07-3.94, P=0.03), but not with moderately or well differentiated gastric cancer. A significant decrease in luciferase activity was observed in rs17103265 deletion allele as compared with the vector containing the rs17103265 T allele (P<0.0001). rs17103265 polymorphism was not associated with the prognosis of gastric cancer patients. SIGNIFICANCE: IkappaBalpha rs17103265 deletion homozygote is a novel genetic risk factor for gastric carcinogenesis, especially for the development of certain subtypes of gastric cancer in southern Chinese population.
机译：目的：发现核因子-κB抑制剂α（IkappaBalpha）多态性与炎性疾病有关。然而，IkappaBalpha多态性与胃癌之间的关联仍然未知。我们的目的是在一项基于人群的中国南方人群病例对照研究中，研究IkappaBalpha多态性与胃癌风险之间的关系。主要方法：1999年至2006年在中国广东省进行了一项基于人群的病例对照研究。本研究共纳入1010例胃癌患者和1500名健康对照。 IkappaBalpha多态性是通过对IkappaBalpha基因（从2kb启动子区域到3.5kb基因组区域）进行测序来鉴定的。通过TaqMan SNP基因分型法分析了IkappaBalpha中的多态性。主要发现：与rs17103265 T纯合子（TT）相比，rs17103265缺失纯合子（-/-）显着增加了胃癌风险（OR = 2.11，95％CI = 1.17-3.83，P = 0.01）。 rs17103265（-/-）基因型与（OR = 2.21，95％CI = 1.19-4.08，P = 0.01）的肠型胃癌风险增加显着相关，但与弥散型或混合型胃癌无关。 rs17103265（-/-）与低分化胃癌有关（OR = 2.05，95％CI = 1.07-3.94，P = 0.03），但与中度或高分化胃癌无关。与包含rs17103265 T等位基因的载体相比，在rs17103265缺失等位基因中观察到萤光素酶活性显着降低（P <0.0001）。 rs17103265基因多态性与胃癌患者的预后无关。意义：IkappaBalpha rs17103265缺失纯合子是胃癌发生，尤其是华南人群某些胃癌亚型发展的新型遗传危险因素。

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