DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression

Jia Yanfei; Hu Rui; Li Ping; Zheng Yan; Wang Yunshan; Ma Xiaoli

首页> 外文期刊>Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association >DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression

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DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression

机译：通过促进Survivin表达，缺氧下胃癌细胞的抗凋亡活性需要DEC1

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Background Human differentiated embryonic chondrocyte-expressed gene 1 (DEC1), which has been reported to be over-expressed in several types of cancer, is associated with tumorigenesis through participation in several biological processes. However, the complex mechanisms underlying DEC1 during carcinogenesis are controversial, and its roles in the development and malignancy of gastric cancer (GC) remain unclear.

机译：背景技术据报道，在几种类型的癌症中据报道，据报道的人分化胚胎软骨细胞表达的基因1（DEC1）与肿瘤引起通过参与几种生物学方法与肿瘤引起相关。然而，致癌物期间DEC1下面的复杂机制是有争议的，其作用在胃癌（GC）的发育和恶性肿瘤中仍然尚不清楚。

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来源
《Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association》 |2018年第4期|共11页
作者
Jia Yanfei; Hu Rui; Li Ping; Zheng Yan; Wang Yunshan; Ma Xiaoli;
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作者单位

Shandong Univ Jinan Cent Hosp Cent Lab Jinan 250013 Shandong Peoples R China;

Shandong Univ Jinan Cent Hosp Dept Reprod Jinan 250013 Shandong Peoples R China;

Shandong Univ Qilu Hosp Dept Clin Lab Jinan 250012 Shandong Peoples R China;

Shandong Univ Jinan Cent Hosp Cent Lab Jinan 250013 Shandong Peoples R China;

Shandong Univ Jinan Cent Hosp Cent Lab Jinan 250013 Shandong Peoples R China;

Shandong Univ Jinan Cent Hosp Cent Lab Jinan 250013 Shandong Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
DEC1; Gastric cancer; Anti-apoptosis; Hypoxia; Survivin;

机译：DEC1;胃癌;抗细胞凋亡;缺氧;survivin;

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专利

1. DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression [J] . Jia Yanfei, Hu Rui, Li Ping, Gastric cancer: official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association . 2018,第4期

机译：通过促进Survivin表达，缺氧下胃癌细胞的抗凋亡活性需要DEC1
2. Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α [J] . OhY.S., KimH.Y., SongI.-C., Oncology reports . 2012,第6期

机译：低氧通过激活缺氧诱导因子-1α诱导胃癌细胞中CXCR4表达和生物学活性。
3. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. [J] . Giatromanolaki A, Koukourakis MI, Sivridis E, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2003,第2期

机译：DEC1（STRA13）蛋白表达与非小细胞肺癌中缺氧诱导因子1-alpha和碳酸酐酶9的过度表达有关。
4. Construction of Lentivira Expression Vector of siRNA Specific for DEC1 and Identification of Its Efficiency in Human Gastric Carcinoma Cell MGC803 [C] . Yan-Fei Jia, Yan Wei, Yan Zheng, 2011 international conference on bioinformatics and biomedical technology . 2011

机译：DEC1特异的siRNA Lentivira表达载体的构建及其在人胃癌细胞MGC803中的效率鉴定
5. Smad3 mediates TGF-beta induced apoptosis through the control of survivin expression in human breast cancer cells. [D] . Song, Dong-Weon. 2005

机译：Smad3通过控制人类乳腺癌细胞中survivin的表达介导TGF-β诱导的细胞凋亡。
6. Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways [O] . Aisha Siddiqa, Linda M Long, Liuxia Li, 2008

机译：HER-2在MCF-7乳腺癌细胞中的表达通过细胞外信号相关激酶（ERK）和磷酸肌醇3激酶（PI3K）信号通路调节抗凋亡蛋白Survivin和Bcl-2
7. DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression [O] . Yanfei Jia, Rui Hu, Ping Li, 2017

机译：通过促进Survivin表达，胃癌细胞在胃癌细胞下的抗凋亡活性需要DEC1

DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression

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