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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study
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Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study

机译：大豆食品和异黄酮的摄入与子宫内膜癌的风险：基于日本公共卫生中心的前瞻性研究

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Objective Compared with western populations, the consumption of soy foods among Japanese is very high and the incidence of endometrial cancer very low. We evaluated the association of soy food and isoflavone intake with endometrial cancer risk in Japanese women. Design Prospective cohort study. Setting Ten public health centre areas in Japan. Population Forty nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey questionnaire. Methods Intakes of soy foods as well as other covariates were assessed in 1995-1998 by a self-administered food frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Main outcome measure Incidence of endometrial cancer. Results During an average of 12.1 years of follow up, 112 newly diagnosed endometrial cancer cases were identified. Energy-adjusted intakes of soy food and isoflavone were not associated with the risk of endometrial cancer. The multivariate-adjusted HR per 25 g/day increase in the intake of soy food was 1.02 (95% CI 0.94-1.10), and the corresponding value for isoflavone intake per 15 mg/day was 1.01 (95% CI 0.841.22). Conclusion In this population-based prospective cohort study of Japanese women, we observed no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk.
机译：目的与西方人群相比，日本人食用大豆食品的比例很高，子宫内膜癌的发生率也很低。我们评估了大豆食品和异黄酮的摄入与日本女性子宫内膜癌风险的关系。设计前瞻性队列研究。在日本设置十个公共卫生中心区域。人口4 119名年龄在45-74岁之间的妇女回答了5年的随访调查问卷。方法1995-1998年间，通过自我管理的食物频率调查问卷评估了大豆食物及其他协变量的摄入量。使用Cox比例风险回归模型估算风险比（HR）和95％置信区间（CI）。主要结果指标子宫内膜癌的发病率。结果在平均12.1年的随访中，共鉴定出112例新诊断的子宫内膜癌病例。能量调节的大豆食品和异黄酮的摄入与子宫内膜癌的风险无关。大豆食品摄入量每增加25 g /天，经多元调整的HR为1.02（95％CI 0.94-1.10），每15 mg /天的异黄酮摄入量对应值为1.01（95％CI 0.841.22） 。结论在这项针对日本女性的人群前瞻性队列研究中，我们没有发现大豆食品或异黄酮摄入与子宫内膜癌风险之间存在保护性关联的证据。

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