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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Factor V Leiden in pregnancies complicated by placental abruption.
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Factor V Leiden in pregnancies complicated by placental abruption.

机译：妊娠合并胎盘早剥的因子V Leiden。

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Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who have had of placental abruption during pregnancy.A retrospective case-control study.University Hospital MAS, Malmo, Sweden.A comparison of 102 women with placental abruption with 2371 prospectively collected controls. Carriership of FV Leiden was determined and the women were interviewed.Proportion of FV Leiden carriership, first degree heritage of thrombosis and previous placental abruption in cases and controls.Carriage of FV Leiden was found in 15.7% of women who have had placental abruption as compared with 10.8% of controls (P = 0.12, odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.9-2.7). Around 20% of women with placental abruption reported first degree heritage for venous thrombosis, as compared with 6.7%of controls (P
机译：最近的研究表明，遗传性或获得性血栓形成的女性携带者中产科并发症的患病率增加。这项研究的目的是确定怀孕期间胎盘早剥的妇女中V因子（FV）莱顿突变（激活的蛋白C [APC]抵抗）的携带者是否更高。一项回顾性病例对照研究。大学医院瑞典马尔默的MAS。将102名女性胎盘早剥与2371名预期收集的对照进行比较。确定FV Leiden的携带者并与妇女进行访谈。在病例和对照中FV Leiden携带者的比例，血栓形成的一级遗传和先前的胎盘早剥。在胎盘早剥的女性中，FV Leiden的携带率为15.7％对照组为10.8％（P = 0.12，优势比[OR] = 1.5，95％置信区间[CI] = 0.9-2.7）。约20％的胎盘早剥妇女报告其一级血栓性静脉血栓形成，而对照组为6.7％（P≤0.001）。FVLeiden携带者在胎盘早剥妇女中无显着差异。但是，胎盘早剥妇女静脉血栓形成的一级遗传学患病率增加，表明胎盘早剥妇女中的血栓形成患病率更高。

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