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首页> 外文期刊>European journal of oral sciences >Inhibitory effects of fruit berry extracts on Streptococcus mutans Streptococcus mutans biofilms
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Inhibitory effects of fruit berry extracts on Streptococcus mutans Streptococcus mutans biofilms

机译：水果浆果萃取物对链球菌的抑制作用（Crephotococcus）链球菌Mutans Biofilms

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摘要

Dark‐colored fruit berries are a rich source of polyphenols that could provide innovative bioactive molecules as natural weapons against dental caries. High‐quality extracts of cranberry, blueberry, and strawberry, and a combination of the three berry extracts (Orophenol), were used to treat 24‐h‐old Streptococcus mutans biofilms. The grown biofilms were treated with the berry extracts at concentrations ranging from 62.5 to 500? μ g?ml ?1 . Treated biofilms were assessed for metabolic activity, acidogenicity, biovolumes, structural organization, and bacterial viability. The biofilms treated with the cranberry and Orophenol extracts exhibited the most significant reductions in metabolic activity, acid production, and bacterial/exopolysaccharide ( EPS ) biovolumes, while their structural architecture appeared less compact than the control‐treated biofilms. The blueberry extract produced significant reductions in metabolic activity and acidogenicity only at the highest concentration tested, without significantly affecting bacterial/ EPS biovolumes or biofilm architecture. Strawberry extracts had no significant effects on S.?mutans biofilms. None of the berry extracts were bactericidal for S.?mutans . The results indicate that cranberry extract was the most effective extract in disrupting S.?mutans virulence properties without significantly affecting bacterial viability. This suggests a potential ecological role for cranberry phenols as non‐bactericidal agents capable of modulating pathogenicity of cariogenic biofilms.
机译：深色水果浆果是丰富的多酚来源，可以提供创新的生物活性分子作为防止龋齿的自然武器。蔓越莓，蓝莓和草莓的优质提取物以及三个浆果提取物（Orophenol）的组合用于治疗24-H型肺炎链球菌变异生物膜。以62.5至500的浓度，用浆液提取物处理生长的生物膜？ μg？ml？1。评估治疗的生物膜进行代谢活性，酸性性，脑血糖，结构组织和细菌活力。用酸丁香和奥菲尔酚提取物处理的生物膜表现出最显着的代谢活性，酸生产和细菌/脱核（EPS）患者的减少，而其结构架构似乎比对照处理的生物膜较小。蓝莓提取物仅在测试的最高浓度下产生了代谢活性和酸性的显着降低，而不会显着影响细菌/ EPS生物玉米或生物膜结构。草莓提取物对S.?mutans生物膜没有显着影响。浆液中没有浆果酶都是杀菌的。结果表明，蔓越莓提取物是破坏S.Omutans毒力学性质的最有效的提取物，而不会显着影响细菌活力。这表明酸丁香酚作为能够调节致癌生物膜的致病性的非杀菌剂的潜在生态作用。

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