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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Danhong Promotes Angiogenesis in Diabetic Mice after Critical Limb Ischemia by Activation of CSE-H2S-VEGF Axis
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Danhong Promotes Angiogenesis in Diabetic Mice after Critical Limb Ischemia by Activation of CSE-H2S-VEGF Axis

机译：通过CSE-H2S-VEGF轴激活临界肢体缺血后，丹洪在临界肢体缺血后促进血管生成

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摘要

The aim of this paper is to investigate effect and mechanism of Danhong injection (DH) on angiogenesis in the diabetic hind limb ischemia mouse model. Thirty diabetic hind limb ischemic model mice and ten normal mice, established by intraperitoneal (i.p.) injection of streptozotocin (STZ) or PBS and ligation/excision of femoral artery, and then twenty diabetic hind limb ischemic model mice of all were evenly randomized to saline (control, n = 10) and DH i.p. injection (2 mL/kg weight for 7 days, n = 10) groups. Limb perfusion recovery and femoral blood hydrogen sulfide (H2S) and vessel regeneration and lower limb vascular endothelial growth factor (VEGF)/cystathionine gamma-lyase (CSE) expression were evaluated during intervention and after euthanasia, respectively. DH i.p. increased ischemic limb perfusion and promoted collateral circulation generation without decreasing blood glucose level. Increased local CSE-H2S-VEGF expression contributed to beneficial effects of DH injection. In conclusion, activation of local CSE-H2S-VEGF axis might participate in proangiogenesis effects of DH injection in diabetic hind limb ischemia model mice, suggesting a potential therapy for diabetic patients with critical limb ischemia.
机译：本文的目的是探讨丹钟注射（DH）对糖尿病后肢缺血小鼠模型血管生成的影响和机制。三十糖尿病后肢缺血模型小鼠和十个正常小鼠，由腹膜内（IP）注射链脲佐菌素（STZ）或PBS和股票的结扎/切除，然后二十令人患糖尿病后肢缺血模型小鼠均匀随机化为盐水（控制，n = 10）和DH IP注射（2ml / kg重量7天，n = 10）组。在干预期间，在干预期间和在安乐死期间，肢体灌注恢复和股骨血氢硫化物（H2S）和血管再生和下肢血管内皮生长因子（VEGF）/胱硫醚γγ-裂解酶（CSE）表达。 dh i.p.增加缺血性肢体灌注和促进侧支循环发电而不降低血糖水平。增加局部CSE-H2S-VEGF表达有助于DH注射的有益效果。总之，局部CSE-H2S-VEGF轴的激活可能参与DH注射液中DH注射在糖尿病后肢缺血模型小鼠的常膜作用，这表明患有临时肢体缺血的糖尿病患者的潜在疗法。

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  • 作者

    Wu Feng; He Zhiqing; Ding Ru; Huang Zhigang; Jiang Qixia; Cui Haiming; Lin Yi; Huang Shuaibo; Dai Xianliang; Zhang Jiayou; Wu Zonggui; Liang Chun;

  • 作者单位

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

    Second Mil Med Univ Shanghai Changzheng Hosp Dept Cardiol Shanghai 200003 Peoples R China;

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  • 正文语种 eng
  • 中图分类 临床医学;
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