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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 5/6 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling
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Jian-Pi-Yi-Shen Decoction Relieves Renal Anemia in 5/6 Nephrectomized Rats: Production of Erythropoietin via Hypoxia Inducible Factor Signaling

机译：建 - 益氏煎汤减轻5/6肾衰竭大鼠的肾血症：通过缺氧诱导因子信号传导生产促红细胞生成素

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摘要

Jian-Pi-Yi-Shen (JPYS) is one of the herbal medicines for treatment of anemic patients with chronic kidney disease (CKD). However, less of scientific evidence to support JPYS involved in treating anemia has been revealed. Here, an animal study was performed to investigate its hematopoietic activities and the underlying mechanism. The 5/6 nephrectomized inductions of CKD anemic rats were randomly divided into two groups: CKD group and JPYS group. Sham-operated rats served as sham group. JPYS (1.36 g/kg/d) was administered orally to CKD rats daily for six consecutive weeks. Results showed that JPYS treatment notably improved renal function and pathological injury in CKD rats. JPYS also restored the hematological parameters, including red blood cells, hemoglobin, and hematocrit. In parallel, the reduction level of EPO was reversed by JPYS. Furthermore, JPYS induced the accumulation of hypoxia inducible factor (HIF)- protein expression. Collectively, these results provide convincing evidence for JPYS decoction in ameliorating CKD-associated anemia, and its mechanism might be related to regulate EPO production via HIF signaling pathway.
机译：建 - 益申（JPYS）是用于治疗血糖患者慢性肾病（CKD）的草药之一。但是，已经揭示了少有关涉及治疗贫血的JPYS的科学证据。在这里，进行动物研究以研究其造血活性和潜在机制。将CKD贫血大鼠的5/6肾病诱导随机分为两组：CKD组和JPYS组。假手术大鼠作为假组。 JPYS（1.36克/ kg / d）在每天口服给CKD大鼠施用，连续六周。结果表明，JPYS治疗显着改善了CKD大鼠的肾功能和病理损伤。 JPYS还恢复了血液学参数，包括红细胞，血红蛋白和血细胞比容。并行地，ePO的减少水平被JPYS逆转。此外，JPYS诱导缺氧诱导因子（HIF） - 蛋白表达的积累。总的来说，这些结果在改善CKD相关贫血中提供了令人信服的证据，其机制可能与通过HIF信号通路调节EPO生产。

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    Chen Jianping; Wang Fochang; Huang Shiying; Liu Xiaoyan; Li Zhonggui; Qi Airong; Liu Xinhui; Yi Tiegang; Li Shunmin;

  • 作者单位

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Shenzhen Key Lab;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Shenzhen Key Lab;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Shenzhen Key Lab;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Dept Nephrol;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Shenzhen Key Lab;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Dept Nephrol;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Dept Nephrol;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Shenzhen Key Lab;

    Guangzhou Univ Chinese Med Clin Med Coll 4 Shenzhen Tradit Chinese Med Hosp Shenzhen Key Lab;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 临床医学;
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